Complete dosage information for Ayahuasca — threshold, light, common, strong, and heavy dose ranges across 1 route of administration.
Full Ayahuasca profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
Fatal ayahuasca overdose from properly prepared traditional brew appears to be extremely rare, though deaths have been reported in ceremonial contexts, typically involving pre-existing health conditions, drug interactions (particularly with serotonergic medications), or consumption of additional substances such as tobacco or toé (scopolamine-containing Brugmansia). Dangerous reactions include: signs of serotonin syndrome (if taken with serotonergic medications) including high fever, muscle rigidity, seizures, and agitation; hypertensive crisis (if combined with tyramine-rich foods) presenting as severe headache, chest pain, and racing heartbeat; severe dehydration from prolonged vomiting and diarrhea; and prolonged psychotic reactions in individuals with predisposition to psychotic disorders. Call emergency services immediately for signs of serotonin syndrome, hypertensive crisis, seizures, or unresponsiveness. If the person is vomiting, keep them in the recovery position to prevent aspiration. Ensure hydration. In a medical setting, cyproheptadine is used for serotonin syndrome, and standard supportive care is provided. Good Samaritan laws apply.
Ayahuasca typically lasts 5–10 hours via oral.