Bromantane Dosage Guide

LD50 of bromantane in mice has been established at 8100 mg/kg. It is strongly recommended that one use harm reduction practices when using this substance. Unlike other stimulants, bromantane does not seem to produce tolerance, addiction, or withdrawal symptoms upon discontinuation. Due to its irregular mechanism of action, it does not exhibit cross-tolerance with other typical stimulants, and anecdotal reports have claimed it can be used to reduce stimulant tolerance, which is caused in part by downregulation of tyrosine hydroxylase which bromantane can increase. - Long term effects Bromantane has been shown to uniquely cause long-term changes to gene expression involved in dopamine metabolism in rats. It is unclear if this effect is relevant to humans. There are multiple anecdotal reports of long-term increases in energy levels, likely from elevated dopamine, from use of bromantane for periods of several months. These effects are claimed to persist even after stopping use of the drug, although have been noted to diminish over time, on a scale of weeks to a month. In a study investigating bromantane in the treatment of neurasthenia, a persistent reduction in fatigue was noted for a month following withdrawal of the drug. - Dangerous Interractions Due to its mechanism of action, bromantane can cause an unexpectedly strong reaction when mixed with other stimulants such as amphetamine, cocaine and/or methylphenidate. It is advised to avoid the use of stimulants with bromantane due to the potential for much stronger reactions than one would expect. - **Germany:** Bromantane is not a controlled substance under the BtMG (*Narcotics Act*) or the NpSG (*New Psychoactive Substances Act*). According to §2 AMG (*Medicines Act*) it would fall under the definition of a medicine because it induces pharmacological effect. By a decision of the European Court of Justice, this definition was declared ineffective because it was not