Clonidine Dosage Guide

LD50 for clonidine in mice is 206 mg/kg and for rats, 465 mg/kg. In humans, lethality is rare with a small number of reported deaths. Morbidity, in terms of cardiorespiratory and CNS dysfunction, generally tends to be more severe in young persons than in adults. - Overdose Symptoms of clonidine overdose include constriction of pupils of the eye, drowsiness, high blood pressure followed by a drop in pressure, irritability, low body temperature, slowed breathing, slowed heartbeat, slowed reflexes, and weakness. There are case reports that show naloxone may be a useful antidote in treating clonidine overdoses. However, this is not in widespread clinical use. -not addictive and has a low potential for abuse. The chronic use of clonidine can produce physical dependence and withdrawal symptoms if one suddenly stops their usage. Clonidine therapy should generally be gradually tapered when discontinuing therapy to avoid rebound hypertension from occurring. Although clonidine is not considered to be addictive, cases of misuse have been documented among certain groups with pre-existing substance use disorders. It is sometimes used in combination with opiates to extend and potentiate their effects. This practice may increase the risk of oversedation and respiratory depression associated with opioid use. - **Germany:** Clonidine is prescription medicine, according to Anlage 1 AMVV. - Switzerland:** Clonidine is listed as a "Abgabekategorie B" pharmaceutical, which requires a prescription. - **United States:** Clonidine is only available with a prescription. - Responsible use - Depressant - Adrenaline (Epinephrine) - Noradrenaline (Norpinephrine) - Clonidine (Wikipedia) - Clonidine (Erowid Vault) - Clonidine (Isomer Design) - Clonidine (Drugs-Forum) - Stähle, H. (2000). A historical perspective: development of clonidine