Diphenhydramine Dosage Guide

Overdose The overdose threshold for diphenhydramine is commonly held to be around 1000 milligrams; however, sensitive individuals or individuals taking other drugs alongside it can overdose with less. The main effects of an overdose are similar to those of heavy doses. Effects include delirium, psychosis, anxiety, confusion, hypotension, dryness, urinary retention, dizziness, dilated pupils and increased heart rate. Some of the more serious side effects at these doses include an even higher risk of seizures and dangerous cardiovascular effects such as arrhythmia (abnormal heartbeat). The user may be completely unable to distinguish reality from hallucinations. For this reason, there is a significant risk of the user responding to a delusional environment and injuring themselves or others, as well as the possibility of engaging in too much physical activity which can further strain the heart or cause rhabdomyolysis. Individuals experiencing delusions should, if possible, not be agitated. The first line of treatment for overdose should be benzodiazepines, although medical attention should always be sought.fatal at amounts close to or exceeding 2 grams. This can result in death, especially when combined with most stimulants, depressants, and MAOIs. - Psychosis Some anecdotal reports suggest that diphenhydramine causes psychosis and delirium at a significantly higher rate than other hallucinogens (i.e. psychedelics and dissociative). There are a large number of experience reports online that describe states of psychotic delirium, amnesia, and other serious consequences after abusing the substance. In many cases, it has resulted in hospitalization and death. The recreational use of diphenhydramine is generally not advised. If deciding to use this substance, one should use extreme caution and harm reduction practices, such as having a sober trip sitter. -produces depe