Kava Dosage Guide

overdose has ever been recorded. The consumption of 'noble' kava root has very low toxicity, however consumption 'tudei' kava and the stems and leaves of kava plants may increase the risk of liver damage. Some research has been done into finding the LD50 of kavalactones with results stating that around 300-400 Mg/Kg daily would be the likely lethal dose based on animal studies. Kava is known to produce a "reverse tolerance" in many users, in a similar fashion to substances like kanna. This means that continued use is required in order to experience full effects. Some users do not experience this. Kava is traditionally regarded as non-addictive especially in comparison to other chemically related drugs such as benzodiazepines. In some Pacific Island communities, there is some record of people who have a psychological addiction to kava and drink it like an alcoholic drinks alcohol. - **Hepatic Route drugs** - Kava inhibits several liver enzymes in the CYP family. Consequentially, combining kava with drugs metabolized via CYP pathways, such as paracetamol, may cause adverse effects. For a list of medications click here A 2010 review concluded that it's possible that ethanol combined with kava may be the cause of kava hepatotoxicity. - **Anticoagulants** - Kava may increase the risk of bleeding if taken with anticoagulants. Specifically the kavalactone kavain. A list of anticoagulants can be found here - **Antiplatelet** - Kava may increase the risk of bleeding if taken with antiplatelet agents. Specifically the kavalactone kavain. A list of antiplatelet agents can be found here In some countries, kava has been banned but in most, it is simply regulated. - Australia** - Kava is regulated by the National Code of Kava Management. Only 18 year olds may have it and can only possess 2 Kg in their baggage. - United Kingdom** - In the UK it is illegal to sell, supply or import any