MAOI Dosage Guide

overdose. - Psychoactive naturally occurring sources with high tyramine content - Psychedelic cacti. The cacti contain contain a bunch of phenethylamines, not just tyramine (but also 3-Methoxytyramine, methyltyramine, hordenine (aka dimethyltyramine), mescaline, etc) and should thus be avoided with MAOIs. However, tyramine has been identified in these species: - Peruvian torch cactus (*Echinopsis peruviana* (syn. *Trichocereus peruvianus*)) - San Pedro cactus (*Echinopsis pachanoi* (syn. *Trichocereus pachanoi*)) - Other cactis: - Psychoactive substances The MAOIs are well-known for their numerous drug interactions, including the following kinds of substances: - Substances that are metabolized by monoamine oxidase, as they can be boosted by up to several-fold - Substances that increase serotonin, noradrenaline, or dopamine activity as too much of any of these neurotransmitters can result in severe acute consequences including serotonin syndrome, hypertensive crisis, and psychosis. - By chemicals - Amino acids, and amino acid metabolism metabolic intermediates - Monoamine precursors - 5-HTP → serotonin - L-DOPA → dopamine, and epinephrine (adrenaline) - L-phenylalanine → L-tyrosine, and phenethylamine: Use with caution, taking phenylalanine while taking MAOIs may cause a severe increase in blood pressure (hypertensive crisis). - L-tryptophan → 5-HTP, and melatonin: May result in short-term serotonin syndrome. - L-tyrosine → L-DOPA, and tyramine: It is unknown if MAOIs interact with tyrosine, so use with caution. - Amino acid metabolism metabolic intermediates - SAM-e → epinephrine (adrenaline) - Adrenergics - Lysergamides: LSA (morning glory: (*Argyreia nervosa*, *Ipomoea tricolor*, etc) - Monoaminergics (MA) - Cholinergics (see also MAOIs that act as acetylcholinesterase inhibitors (AChEIs)), certain substances, examples: *alpha*-GPC (suspected monoaminergic), centrophenoxine, - MAOIs, avoid mixing pure MAOIs. Plants with multiple MAOIs like *Pegan