Psilocin Dosage Guide

No fatal overdoses from psilocin or psilocybin alone have been documented in the medical literature. The lethal dose in humans has never been approached in any reported case. Based on animal toxicology data, a fatal dose in humans would likely require ingestion of several hundred times the typical psychoactive dose — a quantity that is practically impossible to consume. **Acute psychological crisis** is the primary overdose-equivalent presentation. At very high doses, individuals may experience: - Severe panic and terror - Complete ego dissolution with psychotic features (delusions, paranoia) - Extreme disorientation and confusion - Agitation and erratic behavior - Temporary catatonia or unresponsiveness **Management:** - Ensure physical safety: move the person to a calm, safe environment - Reassure them that the effects are drug-induced and temporary ("You have taken a substance. The effects will pass. You are safe.") - Minimize sensory stimulation: dim lights, reduce noise, avoid crowds - Maintain a calm, supportive presence — do not argue with or challenge altered perceptions - A benzodiazepine (e.g., diazepam 5-10 mg oral or midazolam 2-5 mg IM) can be administered if severe anxiety or agitation does not respond to psychosocial support - Antipsychotics (e.g., haloperidol) are sometimes used in emergency departments but should be considered second-line due to potentially worsening the subjective experience - Monitor for hyperthermia, dehydration, and injury - Seek emergency medical attention if seizures occur, if the person has ingested unknown substances alongside psilocin, or if psychotic symptoms persist beyond 6-8 hours