Complete dosage information for Salvia divinorum — threshold, light, common, strong, and heavy dose ranges across 2 routes of administration.
Full Salvia divinorum profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
No fatal overdoses from Salvia divinorum or Salvinorin A have been documented in the medical literature. The compound's extremely low physical toxicity, absence of respiratory depression, minimal cardiovascular effects, and very short duration of action make pharmacological overdose in the traditional sense essentially impossible at any realistic dose. The primary acute risk is **psychological overwhelm**: at high doses, particularly with concentrated extracts, users may experience intense terror, complete dissociation from reality, and total loss of motor control. This can lead to injuries from falls, collisions with objects, or attempts to flee an indoor space. **Management of acute Salvia intoxication:** - Ensure the person is in a safe physical position (sitting or lying down) and cannot injure themselves - Remove any dangerous objects from reach - Speak calmly and minimally — do not attempt to restrain or argue - The acute peak will resolve within 5 to 15 minutes when smoked; simply waiting is usually sufficient - If persistent agitation or panic occurs beyond 30 minutes, a low-dose benzodiazepine (e.g., diazepam 5-10 mg) may be appropriate - No specific antidote exists; the kappa-opioid antagonist norbinaltorphimine (nor-BNI) reverses effects in animal models but is not available clinically - Seek emergency medical attention if the person has sustained a physical injury or exhibits signs of prolonged psychosis
A common Smoked dose of Salvia divinorum is 400–800 µg Salvinorin A.
The threshold dose for Salvia divinorum via Smoked is approximately 100 µg Salvinorin A.
Salvia divinorum typically lasts 15–30 minutes via Smoked.
Salvia divinorum can be taken via Smoked, Sublingual. Each route has different dosage ranges and onset times.