DOI produces 66 documented subjective effects across 7 categories.
Full DOI profileDOI comes on like a slow-building electrical current. For the first one to two hours, the changes are subtle enough to question: a slight sharpening of contrast in the visual field, a faint buzz of energy in the chest, a sense that attention is being involuntarily drawn to detail. Then, incrementally but unmistakably, the analytical character of DOI begins to assert itself. Thoughts become more structured and rigorous, as though the mind has shifted into a higher gear of systematic processing. Patterns in conversation, in music, in the arrangement of objects on a desk, all become more apparent, more interesting, more demanding of examination.
The visual effects emerge with deliberate precision. Colors brighten, but not with the liquid extravagance of DOC. Instead, DOI's palette is cleaner, more defined, almost diagrammatic. Surfaces develop fine geometric overlays that have a technological or architectural quality. Lines become straighter, angles more prominent, and the visual field takes on a kind of enhanced-resolution sharpness, as though perception has been upgraded from standard to high definition. Closed-eye visuals tend toward structured, kaleidoscopic imagery that evolves with mathematical regularity.
At the peak, which establishes itself around three to four hours in and persists for another four to six, the cognitive effects are the dominant feature. DOI lends the mind a tireless, almost compulsive analytical energy. Ideas are dissected, recombined, and examined from multiple perspectives with unusual speed and clarity. This can be deeply productive and insightful, or it can become exhausting, as the mind refuses to rest on any conclusion for long before finding another angle to explore. Emotionally, DOI is less warm than many psychedelics. There is a detachment, a cool objectivity that can feel liberating or sterile depending on the setting. The body is stimulated throughout, with elevated heart rate, jaw tension, mild vasoconstriction, and a persistent restless energy.
The descent is characteristically slow for the DOx family. The analytical intensity gradually softens over many hours, but the stimulation lingers stubbornly. Sleep is typically impossible for twelve to eighteen hours after ingestion. The tail end of the experience often involves a slightly uncomfortable combination of mental fatigue and physical wakefulness, as if the body has not received the memo that the mind is ready to stop. The following day may feel washed-out and flat, though some users report a lasting sense of clarity from the insights generated during the peak.
A distinct decrease in hunger and desire to eat, ranging from reduced interest in food to complete disinterest or even physical revulsion at the thought of eating. This effect can persist for many hours beyond the primary experience.
Bodily control enhancementBodily control enhancement is the subjective feeling of improved physical precision, coordination, and dexterity — a sense of heightened mastery over one's own body that can make movements feel fluid, deliberate, and effortless.
DehydrationA state of insufficient bodily hydration manifesting as persistent thirst, dry mouth, and physical discomfort, often caused by increased sweating, urination, or simply forgetting to drink water during substance use.
DiarrheaDiarrhea is the occurrence of frequent, loose, or watery bowel movements as a side effect of certain psychoactive substances, resulting from either direct GI irritation or pharmacological alterations to gut motility and fluid absorption.
Increased blood pressureIncreased blood pressure (hypertension) is an elevation of arterial pressure above the normal 120/80 mmHg baseline, commonly caused by stimulants, vasoconstrictors, and substances that activate the sympathetic nervous system, posing cardiovascular risks that increase with dose and pre-existing conditions.
Increased heart rateA noticeable acceleration of heartbeat that can range from a subtle awareness of one's pulse to a forceful, rapid pounding felt throughout the chest, neck, and temples. This effect is among the most commonly reported physiological responses to psychoactive substances and often accompanies stimulation, anxiety, or physical exertion during intoxication.
Increased libidoA marked enhancement of sexual desire, arousal, and sensitivity to erotic stimuli that can range from a gentle heightening of romantic interest to an overwhelming, all-consuming preoccupation with sexual thoughts and physical intimacy. This effect often co-occurs with tactile enhancement and empathy, creating a distinctly sensual state of consciousness.
Increased salivationIncreased salivation (hypersalivation or sialorrhea) is the excessive production of saliva beyond what can be comfortably swallowed, commonly occurring with psychedelic tryptamines and certain antipsychotics as part of a broader parasympathetic activation pattern.
Laughter fitsSpontaneous, uncontrollable, and often prolonged episodes of intense laughter that erupt without any identifiable cause or genuine feeling of humor, sometimes persisting to the point of tears, aching muscles, and difficulty breathing or speaking.
NauseaAn uncomfortable sensation of queasiness and stomach discomfort that may or may not lead to vomiting, often occurring during the onset phase of many substances.
Physical euphoriaAn intensely pleasurable bodily sensation that can manifest as waves of warmth, tingling electricity, or a full-body orgasmic glow radiating outward from the core. This effect is often described as one of the most rewarding physical sensations available through psychoactive substances and is a primary driver of the recreational appeal of many substance classes.
Pupil dilationA visible enlargement of the pupil diameter (mydriasis) that can range from subtle widening to dramatic saucer-like expansion where the dark pupil dominates the iris. This effect is one of the most recognizable signs of psychedelic and stimulant intoxication and directly contributes to light sensitivity, enhanced color perception, and the characteristic "wide-eyed" appearance.
SedationA state of deep physical and mental calming that manifests as a progressive desire to remain still, lie down, and eventually drift toward sleep. Sedation ranges from a gentle drowsy relaxation to a heavy, irresistible pull into unconsciousness where maintaining wakefulness becomes a losing battle against the body's insistence on shutdown.
SeizureUncontrolled brain electrical activity causing convulsions and loss of consciousness -- a life-threatening medical emergency requiring immediate help.
StimulationA state of heightened physical and mental energy characterized by increased wakefulness, elevated motivation, and a subjective sense of vigor that pervades both body and mind. Users often report feeling electrically alive, with a buzzing readiness to move, talk, and engage that can range from a pleasant caffeine-like lift to an overwhelming, jittery compulsion to act.
Teeth grindingAn involuntary clenching and rhythmic grinding of the jaw muscles, known clinically as bruxism, that produces a compulsive need to clench, chew, or gnash the teeth together. This effect can range from a subtle tightness in the jaw to forceful, repetitive grinding that can cause significant dental damage and jaw pain during and after the experience.
VasoconstrictionA narrowing of blood vessels throughout the body that produces sensations of cold extremities, tingling in the fingers and toes, and a general feeling of circulatory restriction. Users may notice their hands and feet becoming pale, numb, or uncomfortably cold, sometimes accompanied by a sense of tightness in the chest or head.
A visual phenomenon in which a faint, ghostly imprint of a previously viewed image persists in the visual field after the original stimulus has been removed or one has looked away. These lingering visual echoes are significantly more persistent, vivid, and detailed than normal physiological afterimages, often retaining color and form for several seconds or longer and overlaying themselves onto whatever one currently views.
Brightness alterationPerceived increase or decrease in environmental brightness beyond actual illumination levels, common with stimulants and psychedelics (brightening) or sedatives (darkening).
Colour enhancementAn intensification of the brightness, vividness, and saturation of colors in the external environment, making the world appear dramatically more colorful. Reds seem redder, greens seem greener, and all hues appear richer and more distinct than during ordinary perception.
Colour shiftingThe visual experience of colors on objects and surfaces cycling through continuous, fluid transformations, shifting from one hue to another in smooth, seamless loops. A green surface might flow through blue, purple, red, and back to green in a mesmerizing animated sequence.
Depth perception distortionsAlterations in how the distance of objects within the visual field is perceived, causing layers of scenery to appear exaggerated, rearranged, flattened, or warped in spatial depth.
DiffractionThe experience of seeing rainbow-like spectrums of color and prismatic halos embedded within bright light sources and reflective surfaces, caused by pupil dilation altering how light enters the eye.
DriftingThe visual experience of perceiving stationary objects, textures, and surfaces as appearing to flow, breathe, melt, or shift in position. Drifting is one of the most fundamental and commonly reported visual distortions under the influence of psychedelic substances, serving as the perceptual foundation upon which many other visual effects are built. It manifests as a fluid, organic sense of motion embedded in otherwise static visual fields.
External hallucinationA visual hallucination that manifests within the external environment as though it were physically real, ranging from subtle distortions of existing objects to fully autonomous, detailed scenes and entities that appear indistinguishable from reality.
GeometryThe experience of perceiving complex, ever-shifting geometric patterns superimposed over the visual field or visible behind closed eyelids. Geometry is widely considered the hallmark visual effect of psychedelic substances, ranging from simple lattice patterns and honeycombs at low doses to infinitely complex, self-transforming fractal structures at high doses that can feel profoundly meaningful and awe-inspiring.
Internal hallucinationVivid, detailed visual experiences perceived within an imagined mental landscape that can only be seen with closed eyes, ranging from fleeting imagery and abstract scenes to fully immersive, dream-like environments with autonomous narratives and entities.
Pattern recognition enhancementAn increased ability and tendency to perceive meaningful patterns, faces, and images within ambiguous or random visual stimuli such as textures, clouds, and surfaces.
Perspective distortionsDistortion of perceived depth, distance, and size of real objects, making things appear closer, further, larger, or smaller than they actually are.
Perspective hallucinationA hallucinatory phenomenon in which the observer's visual perspective shifts from the normal first-person viewpoint to alternative vantage points — including third-person (seeing oneself from outside), bird's-eye, or omniscient perspectives — during both internal and external hallucinations.
Settings, sceneries, and landscapesThe perceived environment in which hallucinatory experiences take place, ranging from recognizable locations drawn from memory to entirely novel alien landscapes, ancient civilizations, cosmic vistas, and impossible architectural spaces.
Shadow peopleThe perception of dark, humanoid silhouettes lurking in peripheral vision or standing in direct line of sight, appearing to move and behave as autonomous, sentient beings. These entities feel disturbingly real and are a hallmark of deliriant intoxication and sleep deprivation.
Symmetrical texture repetitionTextures appear to mirror and tessellate across surfaces in intricate, self-similar symmetrical patterns that maintain detail at every scale. Most prominent in peripheral vision on rough surfaces.
TracersMoving objects leave visible trails of varying length and opacity behind them, similar to long-exposure photography. Trails may match the object color or appear in other hues.
TransformationsObjects and scenery undergo perceived visual metamorphosis, smoothly shapeshifting into other recognizable forms over seconds. Patterns morph into faces, animals, and imagery.
Visual acuity enhancementVision becomes sharper and more defined than normal, as though a slightly blurry lens has been brought into perfect focus. Edges appear crisp and fine details become vivid.
A complete or partial inability to form new memories or recall existing ones during and after substance use, ranging from minor gaps in recollection to total blackouts encompassing hours of experience.
Analysis enhancementA perceived improvement in one's ability to logically deconstruct concepts, recognize patterns, and reach novel conclusions, often accompanied by deep states of contemplation and an abundance of insightful ideas.
AnxietyIntense feelings of apprehension, worry, and dread that can range from a subtle background unease to overwhelming panic attacks with a sense of impending doom, often amplified by the substance's intensification of one's existing mental state.
Cognitive euphoriaA cognitive and emotional state of intense well-being, elation, happiness, and joy that manifests as a profound mental contentment and positive outlook. This ranges from gentle feelings of optimism and warmth to overwhelming bliss that pervades all thoughts and perceptions.
Conceptual thinkingA shift in the nature of thought from verbal, linear sentence structures to intuitive, non-linguistic concepts that are felt and understood rather than spoken by an internal narrator.
ConfusionAn impairment of abstract thinking marked by a persistent inability to grasp or comprehend concepts and situations that would normally be perfectly understandable during sobriety.
DelusionA delusion is a fixed, false belief that is held with unshakeable certainty and is impervious to contradicting evidence or rational argument — often involving grandiose, persecutory, or bizarre themes that are clearly at odds with observable reality.
Immersion enhancementA heightened capacity to become fully absorbed and engrossed in external media such as music, films, video games, and art, with an amplified suspension of disbelief and a deepened emotional connection to the content being experienced.
Increased sense of humorA general amplification of one's sensitivity to finding things humorous and amusing, often causing previously unremarkable stimuli to become inexplicably hilarious, with laughter triggered by observations and connections that seem profound or absurd in the altered state.
ManiaAbnormally elevated mood, energy, and activity with impulsive behavior and grandiosity, associated with stimulant use and certain drug interactions.
Memory suppressionA dose-dependent inhibition of one's ability to access and utilize short-term and long-term memory, ranging from mild forgetfulness to a profound inability to recall personal identity, biographical information, or the context of the current experience.
Novelty enhancementA feeling of increased fascination, awe, and childlike wonder attributed to everyday concepts, objects, and experiences, as if perceiving the world for the first time.
Panic attackA panic attack is a discrete episode of acute, overwhelming fear or terror that arises suddenly and peaks within minutes, accompanied by distressing physical symptoms including rapid heartbeat, shortness of breath, chest tightness, trembling, dizziness, and a profound sense that one is dying, going insane, or losing control.
ParanoiaIrrational suspicion and belief that others are watching, plotting against, or intending harm toward oneself, ranging from mild unease to overwhelming terror.
Personal bias suppressionA decrease in the personal, cultural, and cognitive biases through which one normally filters their perception, enabling more objective self-examination and worldview analysis.
Personal meaning enhancementPersonal meaning enhancement is a state in which everyday events, coincidences, song lyrics, environmental details, and social interactions seem to carry profound and specific personal significance — as if the universe is communicating directly with the experiencer through symbolism and synchronicity.
PsychosisPsychosis is a serious psychiatric state involving a fundamental break from consensus reality — characterized by firmly held false beliefs (delusions), perception of things that are not there (hallucinations), disorganized thought and speech, and a loss of the ability to distinguish internal mental events from external reality.
Sensed presenceSensed presence is the vivid and often unshakeable feeling that an unseen conscious being — whether benevolent, malevolent, neutral, or inscrutable — is present nearby or within one's own mind, despite the complete absence of any visual, auditory, or tactile confirmation.
Thought accelerationThe experience of thoughts occurring at a dramatically increased rate, as if the mind has been shifted into a higher gear. Ideas, associations, and internal dialogue cascade rapidly, often outpacing the ability to articulate or fully process each one, producing a subjective sense of heightened mental velocity.
Thought connectivityA state in which disparate thoughts, concepts, and ideas become fluidly and spontaneously interconnected, revealing patterns and relationships that are normally overlooked. The mind weaves together seemingly unrelated subjects into a unified web of associations, often producing novel insights or a profound sense of conceptual coherence.
Thought loopsBecoming trapped in a repeating cycle of thoughts, actions, and emotions that loops every few seconds to minutes. Short-term memory lapses cause the sequence to restart.
Time distortionSubjective perception of time becomes dramatically altered — minutes may feel like hours, or hours pass in moments. Can manifest as either dilation or compression.
WakefulnessAn increased ability to stay awake and alert without the desire to sleep. Distinct from stimulation in that it does not elevate energy above a naturally rested baseline.
Scenarios and plots are the narrative structures that emerge within hallucinatory states — coherent or surreal storylines involving autonomous characters, unfolding events, and immersive settings that can feel as real and consequential as waking life.
SynaesthesiaStimulation of one sense triggers involuntary experiences in another — seeing sounds as colors, tasting textures, or hearing visual patterns. A blending of sensory channels.
A profound dissolution of the sense of self in which personal identity, memories, and the boundary between self and world completely vanish, leaving only pure undifferentiated awareness.
Existential self-realizationA sudden, visceral realization of the profound significance and improbability of one's own existence as a conscious being within the universe, often accompanied by overwhelming awe and a fundamental shift in perspective about life and reality.
Unity and interconnectednessA profound sense that identity extends beyond the self to encompass other people, nature, or all of existence. Boundaries between self and other dissolve into felt oneness.
DOI can produce 18 physical effects including appetite suppression, increased heart rate, tactile enhancement, vasoconstriction, and 14 more.
Yes. DOI can produce 19 visual effects including settings, sceneries, and landscapes, pattern recognition enhancement, symmetrical texture repetition, depth perception distortions, and 15 more.
DOI produces 23 cognitive effects including personal bias suppression, increased sense of humor, immersion enhancement, thought connectivity, and 19 more.