Complete dosage information for O-PCE — threshold, light, common, strong, and heavy dose ranges across 2 routes of administration.
Full O-PCE profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
Overdose on O-PCE can range from unpleasant to life-threatening depending on the dose, route, and whether other substances are involved. **Signs of overdose**: Severe nystagmus, complete unresponsiveness, vomiting (aspiration risk while unconscious), severely depressed breathing, seizures, extremely elevated heart rate or blood pressure. **Critical dangers**: - **Respiratory depression**: Particularly when combined with other depressants - **Aspiration**: Loss of protective reflexes combined with nausea creates choking risk - **Hyperthermia or hypothermia**: Impaired thermoregulation at high doses **Emergency response**: Place the person in the recovery position. Monitor breathing. Call emergency services if breathing is slow, shallow, or irregular; if the person is unresponsive to stimulation; or if seizures occur. Be honest with medical personnel about what was consumed — they are there to help, not to judge.
A common insufflated dose of O-PCE is 6–12 mg.
The threshold dose for O-PCE via insufflated is approximately 2 mg.
O-PCE typically lasts 3–5 hours via insufflated.
O-PCE can be taken via insufflated, oral. Each route has different dosage ranges and onset times.