O-PCE

O-PCE (2'-oxo-PCE, also called Eticyclidine or 2-oxo-PCE) is a synthetic dissociative of the arylcyclohexylamine class, structurally related to both ketamine (sharing the 2'-oxo cyclohexyl group) and PCE (sharing the N-ethyl substitution). It is among the most potent and widely discussed of the novel dissociatives, with a substantial community experience base documenting a powerful, predominantly NMDA-antagonist dissociation that community members describe as "cold," "analytical," and more overtly PCP-like than ketamine or DCK.

Community documentation of O-PCE is rich and candid. Reports describe a potent dissociative experience that demands careful dose management — one community member describes 15 mg insufflated as producing a dissociation that is "cold" and "analytical" with a character "very different from MXE or DCK." Another post raises the unusual situation of a user who developed an apparent allergic reaction to O-PCE. A thread speculating about O-PCPr (an O-PCE analog) reflects the community's scientific engagement with the structural class. Community warnings about vaping chemicals in general reference O-PCE implicitly.

O-PCE's high potency — active at doses as low as 5–10 mg — combined with its longer duration (3–5 hours) and steep dose-response curve make it one of the more technically demanding dissociatives to use safely. Its effect profile, community members note, is closer to PCP than to ketamine — making it inappropriate for beginners and requiring experienced dissociative users to recalibrate expectations.