MET

N-Methyl-N-ethyltryptamine (MET) is a synthetic psychedelic tryptamine structurally analogous to DMT, differing only in having one methyl and one ethyl group on the terminal nitrogen rather than two methyl groups. This seemingly minor structural modification substantially alters the compound's pharmacokinetic profile — MET demonstrates at least partial oral bioavailability unlike DMT, owing to reduced affinity for monoamine oxidase A. Alexander Shulgin documented MET in TiHKAL (1997), providing the synthesis route and early subjective effect notes that sparked subsequent community investigation.

MET has accumulated the most substantial community documentation of any compound in this batch, with over 20 Reddit posts indexed in the database. Community reports describe a psychedelic experience with qualities frequently distinguished from DMT and other symmetric tryptamines — a character many describe as "spacious," emotionally warm, and significantly visual, with a cleaner mental quality than some other tryptamines. Users frequently compare it favorably to DMT, noting that the oral activity and somewhat longer duration (typically 3–5 hours) make it more practically accessible for intentional use than smoked DMT.

The Reddit community documentation for MET reflects significant diversity of use context — from personal introspective sessions to discussions of harm reduction principles, comparisons with other compounds, and philosophical and spiritual exploration. This breadth of discussion underscores MET's position as one of the more actively investigated synthetic tryptamines in the contemporary psychedelic community.