How long does Oxiracetam last?

The total duration of Oxiracetam via oral is 8 hours to 10 hours. Onset typically occurs within 30 minutes to 1.5 hours.

Oxiracetam — SubstanceWiki

Oxiracetam

Racetams · Stimulants, Nootropic

7 dangerous interactions — combining Oxiracetam with certain substances may be life-threatening.

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Stimulants, Nootropic(Racetams)

Quick Dosage

oral1200–1800 mg (common)

Total duration (oral)8hr–10hr

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Oxiracetam is a synthetic nootropic and mild stimulant of the racetam family, first synthesized in the 1970s. Among the classical racetams (piracetam, aniracetam, oxiracetam, pramiracetam), it is particularly notable for its stimulant properties, which distinguish it from the more sedating or anxiety-modulating profiles of aniracetam. Users and researchers have described oxiracetam as having a more "clean" stimulant quality — increased alertness, focus, and energy without the cardiovascular effects or anxiety associated with traditional stimulants. This combination of cognitive enhancement and stimulation has made it popular for demanding mental tasks including studying, technical work, and analytical problem-solving.

Like all racetams, oxiracetam is thought to exert its primary effects through positive allosteric modulation of AMPA receptors and enhancement of acetylcholine release in hippocampal neurons. Unlike aniracetam, which has additional anxiolytic effects through GABAergic and monoaminergic mechanisms, oxiracetam's effects are more focused on the glutamatergic and cholinergic systems, producing a more cognitively "activating" rather than mood-modulating experience. Several users in experience reports describe it as distinctly effective for tasks requiring sustained logical thinking, technical analysis, and pattern recognition.

The clinical evidence for oxiracetam, like most racetams, is primarily derived from trials in elderly patients with organic cognitive impairment. Studies in Alzheimer's disease and multi-infarct dementia patients have shown improvements in memory and cognitive function. Evidence in healthy adults is limited to a smaller body of literature. Oxiracetam is approved as a pharmaceutical in some European countries and is sold as an unregulated supplement in the United States and United Kingdom.

How It Feels

Oxiracetam arrives with the subtlety that characterizes the racetam family, but it carries a mild stimulating edge that distinguishes it from its gentler relatives. Within an hour of oral ingestion, there is a quiet sharpening of focus and a barely perceptible increase in alertness. The mind does not feel altered so much as optimized, as though the signal-to-noise ratio of thought has been marginally improved. Attention locks onto tasks with slightly less effort, and the tendency to drift or daydream is gently curtailed.

At its peak, typically reached within one to two hours, oxiracetam provides a modest enhancement of cognitive function with a subtle stimulant quality. Logical reasoning and analytical thinking are the primary beneficiaries. Tasks that involve sequential logic, problem-solving, or working with structured information feel slightly more natural and less effortful. There is a clarity to thought that is particularly noticeable during tasks that would normally produce mental fatigue. The mild stimulation manifests not as physical energy but as a sustained mental freshness, an ability to remain cognitively engaged for longer than usual without the creeping fog of mental exhaustion.

The emotional and physical effects are minimal. Mood may be very slightly elevated, attributable more to the satisfaction of thinking clearly than to any direct pharmacological action on affect. The body feels normal and comfortable. There are no notable physical side effects at standard doses: no jaw tension, no cardiovascular changes, no appetite suppression worth mentioning. The compound is remarkable for how little it disturbs the body's ordinary operation while gently improving the mind's.

The effects last four to six hours and taper without incident. There is no crash, no rebound, and no interference with sleep if the dose is timed appropriately. The following morning is unremarkable. The overall experience of oxiracetam is one of gentle, reliable cognitive support, a compound that enhances thinking without altering consciousness and improves performance without exacting a price. It is the sort of substance that earns appreciation through consistent utility rather than any single dramatic experience.

Pharmacology

Mechanism of Action

AMPA Receptor Potentiation

Oxiracetam is a positive allosteric modulator of AMPA-type ionotropic glutamate receptors, sharing this primary mechanism with aniracetam and the broader ampakine class. It slows the desensitization of AMPA receptors following glutamate binding, prolonging excitatory synaptic transmission and facilitating long-term potentiation in the hippocampus and cortex. This glutamatergic enhancement underlies its effects on memory formation, learning, and cognitive processing speed.

Cholinergic Enhancement

Oxiracetam increases acetylcholine release within hippocampal neurons, as demonstrated in animal studies using microdialysis techniques. The mechanism is likely indirect — enhanced glutamatergic activity stimulates cholinergic interneuron firing, increasing ACh release from the hippocampal cholinergic system. This cholinergic component accounts for both oxiracetam's memory-enhancing properties and the characteristic headaches that some users experience when choline substrate is insufficient.

Protein Kinase C Activation

Oxiracetam has been shown to activate protein kinase C (PKC) in neuronal membranes. PKC is a critical signaling enzyme involved in synaptic plasticity, neurotransmitter release, and receptor trafficking. PKC activation may contribute to long-term changes in synaptic strength that outlast the period of direct receptor modulation.

Mild Stimulant Mechanisms

The stimulant quality of oxiracetam compared to other racetams may reflect its stronger enhancement of excitatory glutamatergic transmission relative to any inhibitory or monoaminergic effects. The net outcome is a state of elevated alertness and mental activation that users distinguish from caffeine (no cardiovascular component) and from ADHD medications (no dopaminergic component).

Pharmacokinetics

Oxiracetam is water-soluble (unlike aniracetam) and does not require fat for absorption. It is absorbed efficiently with oral bioavailability of approximately 68–82%. Peak plasma concentrations are reached in 1–3 hours. The half-life is approximately 8–10 hours — longer than aniracetam — which allows once or twice daily dosing. It is excreted primarily in urine.

Interactions

Substance	Status	Note
Atropa belladonna	Dangerous	Extreme cardiovascular strain from anticholinergic and stimulant effects combined
Datura	Dangerous	Extreme cardiovascular strain from anticholinergic and stimulant effects combined
Diphenhydramine	Dangerous	Extreme cardiovascular strain from anticholinergic and stimulant effects combined
Harmala alkaloid	Dangerous	Risk of hypertensive crisis and serotonin syndrome; potentially fatal combination
MAOI	Dangerous	Risk of hypertensive crisis and serotonin syndrome; potentially fatal combination
Myristicin	Dangerous	Extreme cardiovascular strain from anticholinergic and stimulant effects combined
Peganum harmala	Dangerous	Risk of hypertensive crisis and serotonin syndrome; potentially fatal combination
1,3-Butanediol	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
1,4-Butanediol	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
1B-LSD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
1cP-AL-LAD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
1cP-LSD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
1cP-MiPLA	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
1P-ETH-LAD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
1P-LSD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
1V-LSD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2-Aminoindane	Caution	Increased cardiovascular strain and neurotoxicity risk
2-FA	Caution	Increased cardiovascular strain and neurotoxicity risk
2-FEA	Caution	Increased cardiovascular strain and neurotoxicity risk
2-FMA	Caution	Increased cardiovascular strain and neurotoxicity risk
2,5-DMA	Caution	Increased cardiovascular strain and neurotoxicity risk
25B-NBOH	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
25B-NBOMe	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
25C-NBOH	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
25C-NBOMe	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
25D-NBOMe	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
25E-NBOH	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
25I-NBOH	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
25I-NBOMe	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
25N-NBOMe	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-B	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-B-FLY	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-C	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-D	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-E	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-H	Caution	Increased cardiovascular strain and neurotoxicity risk
2C-I	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-P	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-T	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-T-2	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-T-21	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2C-T-7	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
2M2B	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-FA	Caution	Increased cardiovascular strain and neurotoxicity risk
3-FEA	Caution	Increased cardiovascular strain and neurotoxicity risk
3-FMA	Caution	Increased cardiovascular strain and neurotoxicity risk
3-FPM	Caution	Increased cardiovascular strain and neurotoxicity risk
3-MMC	Caution	Increased cardiovascular strain and neurotoxicity risk
3,4-CTMP	Caution	Increased cardiovascular strain and neurotoxicity risk
3C-E	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
3C-P	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-AcO-DET	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-AcO-DiPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-AcO-DMT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-AcO-MET	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-AcO-MiPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-FA	Caution	Increased cardiovascular strain and neurotoxicity risk
4-FMA	Caution	Increased cardiovascular strain and neurotoxicity risk
4-HO-DET	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-HO-DiPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-HO-DPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-HO-EPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-HO-MET	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-HO-MiPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-HO-MPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
4-MMC	Caution	Increased cardiovascular strain and neurotoxicity risk
4F-EPH	Caution	Increased cardiovascular strain and neurotoxicity risk
4F-MPH	Caution	Increased cardiovascular strain and neurotoxicity risk
5-APB	Caution	Increased cardiovascular strain and neurotoxicity risk
5-MeO-DALT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
5-MeO-DiBF	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
5-MeO-DiPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
5-MeO-DMT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
5-MeO-MiPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
6-APB	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
6-APDB	Caution	Increased cardiovascular strain and neurotoxicity risk
8-Chlorotheophylline	Caution	Increased cardiovascular strain and neurotoxicity risk
A-PHP	Caution	Increased cardiovascular strain and neurotoxicity risk
A-PVP	Caution	Increased cardiovascular strain and neurotoxicity risk
Acetylfentanyl	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Adrafinil	Caution	Increased cardiovascular strain and neurotoxicity risk
AL-LAD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Alcohol	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
ALD-52	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Allylescaline	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Alprazolam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Amphetamine	Caution	Increased cardiovascular strain and neurotoxicity risk
Armodafinil	Caution	Increased cardiovascular strain and neurotoxicity risk
Ayahuasca	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Baclofen	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Benzodiazepines	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Benzydamine	Caution	Increased cardiovascular strain and neurotoxicity risk
Bromantane	Caution	Increased cardiovascular strain and neurotoxicity risk
Bromo-DragonFLY	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Bufotenin	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Buprenorphine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Butylone	Caution	Increased cardiovascular strain and neurotoxicity risk
Caffeine	Caution	Increased cardiovascular strain and neurotoxicity risk
Cake	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Carisoprodol	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Clonazepam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Clonazolam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Clonidine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Cocaine	Caution	Increased cardiovascular strain and neurotoxicity risk
Codeine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Cyclazodone	Caution	Increased cardiovascular strain and neurotoxicity risk
Deschloroetizolam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Desomorphine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Desoxypipradrol	Caution	Increased cardiovascular strain and neurotoxicity risk
DET	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Dextroamphetamine	Caution	Increased cardiovascular strain and neurotoxicity risk
Dextropropoxyphene	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Diazepam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Dichloropane	Caution	Increased cardiovascular strain and neurotoxicity risk
Diclazepam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Dihydrocodeine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
DiPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
DMT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
DOB	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
DOC	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
DOI	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
DOM	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
DPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Efavirenz	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Ephedrine	Caution	Increased cardiovascular strain and neurotoxicity risk
Ephylone	Caution	Increased cardiovascular strain and neurotoxicity risk
EPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Escaline	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Eszopiclone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
ETH-CAT	Caution	Increased cardiovascular strain and neurotoxicity risk
ETH-LAD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Ethylmorphine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Ethylone	Caution	Increased cardiovascular strain and neurotoxicity risk
Ethylphenidate	Caution	Increased cardiovascular strain and neurotoxicity risk
Etizolam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
F-Phenibut	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Fenethylline	Caution	Increased cardiovascular strain and neurotoxicity risk
Fentanyl	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Flualprazolam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Flubromazepam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Flubromazolam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Flunitrazepam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Flunitrazolam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Gabapentin	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Gaboxadol	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
GBL	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
GHB	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Grayanotoxin	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Heroin	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Hexedrone	Caution	Increased cardiovascular strain and neurotoxicity risk
Hydrocodone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Hydromorphone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Ibogaine	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Isopropylphenidate	Caution	Increased cardiovascular strain and neurotoxicity risk
Kratom	Caution	Increased cardiovascular strain and neurotoxicity risk
LAE-32	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Lisdexamfetamine	Caution	Increased cardiovascular strain and neurotoxicity risk
Lorazepam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
LSA	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
LSD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
LSM-775	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
LSZ	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
MCPP	Caution	Increased cardiovascular strain and neurotoxicity risk
MDA	Caution	Increased cardiovascular strain and neurotoxicity risk
MDMA	Caution	Increased cardiovascular strain and neurotoxicity risk
MDPV	Caution	Increased cardiovascular strain and neurotoxicity risk
Mephedrone	Caution	Increased cardiovascular strain and neurotoxicity risk
Mephenaqualone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Mescaline	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
MET	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Methadone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Methallylescaline	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Methamphetamine	Caution	Increased cardiovascular strain and neurotoxicity risk
Methaqualone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methcathinone	Caution	Increased cardiovascular strain and neurotoxicity risk
Methiopropamine	Caution	Increased cardiovascular strain and neurotoxicity risk
Methylnaphthidate	Caution	Increased cardiovascular strain and neurotoxicity risk
Methylone	Caution	Increased cardiovascular strain and neurotoxicity risk
Methylphenidate	Caution	Increased cardiovascular strain and neurotoxicity risk
Metizolam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Mexedrone	Caution	Increased cardiovascular strain and neurotoxicity risk
Midazolam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MiPLA	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
MiPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Mirtazapine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Modafinil	Caution	Increased cardiovascular strain and neurotoxicity risk
Morphine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
MPT	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
N-Ethylhexedrone	Caution	Increased cardiovascular strain and neurotoxicity risk
N-Methylbisfluoromodafinil	Caution	Increased cardiovascular strain and neurotoxicity risk
Naloxone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
NEP	Caution	Increased cardiovascular strain and neurotoxicity risk
Nicotine	Caution	Increased cardiovascular strain and neurotoxicity risk
Nifoxipam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
NM-2-AI	Caution	Increased cardiovascular strain and neurotoxicity risk
O-Desmethyltramadol	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Oxycodone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Oxymorphone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
PARGY-LAD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Pentedrone	Caution	Increased cardiovascular strain and neurotoxicity risk
Pentobarbital	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Pethidine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Phenobarbital	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Phenylpiracetam	Caution	Increased cardiovascular strain and neurotoxicity risk
PRO-LAD	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Psilocybin Mushrooms	Caution	Increases anxiety, cardiovascular stress, and psychological intensity
Rhodiola Rosea	Caution	Increased cardiovascular strain and neurotoxicity risk
SAMe	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other

Toxicity & Safety

Acute Toxicity

Oxiracetam has a very low acute toxicity profile. No human fatalities from oxiracetam toxicity have been reported. Animal studies place the LD50 at doses far exceeding any human supplemental use.

Common Side Effects

Headache: the most commonly reported side effect, attributable to increased ACh demand without adequate choline; co-supplementation with Alpha-GPC or citicoline is the standard solution
Insomnia: significant concern; the stimulant quality means evening or late-afternoon dosing will disrupt sleep in most users
Anxiety and irritability: more common than with piracetam, reflecting oxiracetam's stimulant properties
Nausea: occasional, particularly without food

Stimulant Profile

Unlike aniracetam (which has anxiolytic properties), oxiracetam's stimulant quality means that users with pre-existing anxiety, sleep difficulties, or stimulant sensitivity should approach it with particular caution. Combination with caffeine or other stimulants amplifies both the cognitive activation and potential anxiety.

Tolerance

No formal studies; community experience suggests tolerance develops with continuous daily use, though more slowly than with omberacetam. Cycling (e.g., weekdays on, weekends off; or 3 weeks on, 1 week off) is recommended.

Drug Interactions

CNS stimulants (caffeine, modafinil, amphetamines): additive stimulation and anxiety risk
Anticholinergic medications: pharmacological opposition
Cholinesterase inhibitors: additive cholinergic effects

Addiction Potential

non-addictive with a low potential for abuse

Overdose Information

LD50) of oxiracetam has not been officially published as it has low abuse potential, but is not known to be harmful in it's recommended dosage range. -non-addictive with a low potential for abuse. It does not seem to be capable of causing psychological dependence among users, although this fact has not been corroborated by clinical studies.develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that,3 - 71 - 2 weeks to be back at baseline (in the absence of further consumption). Oxiracetam may presents cross-tolerance with Cross-all racetam nootropics, meaning that after the consumption of oxiracetam certain nootropics such as aniracetam and piracetam may have a reduced effect.

Oxiracetam, being a member of the racetam family, currently is legally available to buy and sell in most countries, but may still vary by region.

United Kingdom** - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
Responsible use
Pramiracetam
Nootropic
Stimulant
Piracetam
Oxiracetam (Wikipedia)
Oxiracetam (Erowid Vault)
Oxiracetam (Isomer Design)
Oxiracetam (Examine)

Full	develops with prolonged and repeated use
Half	3 - 7 days
Zero	1 - 2 weeks

Oxiracetam

Quick Dosage

Dosage

oral

Duration

oral

How It Feels

Subjective Effects

Physical Effects

Physical(5)

Cognitive & Perceptual Effects

Cognitive(2)

Pharmacology

Mechanism of Action

AMPA Receptor Potentiation

Cholinergic Enhancement

Protein Kinase C Activation

Mild Stimulant Mechanisms

Pharmacokinetics

Interactions

History

Synthesis and Early Research

Clinical Investigation

Nootropic Community History

Harm Reduction

Dosing

Timing is Critical

Choline Co-supplementation

Managing the Stimulant Quality

Cycling

Comparison with Other Racetams

Toxicity & Safety

Acute Toxicity

Common Side Effects

Stimulant Profile

Tolerance

Drug Interactions

Addiction Potential

Overdose Information

Dangerous Interactions

Tolerance

Cross-tolerances

Legal Status

Experience Reports (2)

Tips (8)

Community Discussions (4)

See Also

References (5)

Frequently Asked Questions