What are the effects of O-Desmethyltramadol?

O-Desmethyltramadol is tramadol's active metabolite stripped of its parent compound's noradrenergic and serotonergic complications, and the resulting experience is cleaner, more purely opioid in character. The onset takes thirty to sixty minutes, a patient accumulation of warmth that begins as a fai

Is O-Desmethyltramadol addictive?

moderately addictive with a high potential for abuse

What are the risks of O-Desmethyltramadol?

Further information: Research chemicals § Toxicity and harm potential O-DSMT has a moderate potential toxicity relative to its dose due to its potency. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss. It is also potentially lethal when mixed

How long does O-Desmethyltramadol last?

The total duration of O-Desmethyltramadol via intravenous is 5 hours to 8 hours. Onset typically occurs within 10 seconds to 15 seconds. Peak effects last 2 hours to 5 hours.

O-Desmethyltramadol — SubstanceWiki

Opioid painkiller medication

Desmetramadol (INNTooltip International Nonproprietary Name), also known as O-desmethyltramadol (O-DSMT), is an opioid analgesic and the main active metabolite of tramadol. Tramadol is demethylated by the liver enzyme CYP2D6 to desmetramadol in the same way as codeine, and so similarly to the variation in effects seen with codeine, individuals who have a less active form of CYP2D6 will tend to have reduced analgesic effects from tramadol. Because desmetramadol itself does not need to be metabolized to induce an analgesic effect, it can be used in individuals with CYP2D6 inactivating mutations.

Desmetramadol is commonly encountered as a designer drug online in powder form or as an ingredient in pressed pills due to being unscheduled in many jurisdictions. Outside of its role as a metabolite, a chemical used in research, and as a recreational drug, desmetramadol has a very limited history of human usage and is not approved for medicinal use in any country as of 2025.

Substance	Status	Note
3-Cl-PCP	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-HO-PCE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-HO-PCP	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-MeO-PCE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-MeO-PCMo	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-MeO-PCP	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
4-MeO-PCP	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Alcohol	Dangerous	—
Atropa belladonna	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Benzodiazepines	Dangerous	—
Cake	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Datura	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Deschloroetizolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Deschloroketamine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Desomorphine	Dangerous	Compounding respiratory depression and overdose risk
Diclazepam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Diphenhydramine	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Diphenidine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Ephenidine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Eszopiclone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Etizolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Flubromazepam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Flubromazolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Flunitrazepam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Flunitrazolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Gaboxadol	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
GBL	Dangerous	—
GHB	Dangerous	—
Harmala alkaloid	Dangerous	Risk of serotonin syndrome and severe respiratory depression; potentially fatal
HXE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Inhalants	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Ketamine	Dangerous	—
Lorazepam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Memantine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Mephenaqualone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Metizolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Midazolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
MXiPr	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Naloxone	Dangerous	Compounding respiratory depression and overdose risk
Nicotine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Nifoxipam	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
O-PCE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
PCE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Peganum harmala	Dangerous	Risk of serotonin syndrome and severe respiratory depression; potentially fatal
Pentobarbital	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Phenobarbital	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
SAMe	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
3-FMA	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
4-MMC	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
8-Chlorotheophylline	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Adrafinil	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Benzydamine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Bromantane	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Dichloropane	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Ephedrine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Hexedrone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Methcathinone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Oxiracetam	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Phenylpiracetam	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Rhodiola Rosea	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Nitrous	Uncertain	—
Psilocybin Mushrooms	Low Risk & No Synergy	No significant pharmacological interaction; opioids may slightly dull the psychedelic experience

Full	develops with prolonged and repeated use
Half	3 - 7 days
Zero	1 - 2 weeks

O-Desmethyltramadol

Quick Dosage

Dosage

intravenous

oral

sublingual

Duration

intravenous

oral

sublingual

How It Feels

Subjective Effects

Physical Effects

Physical(15)

Cognitive & Perceptual Effects

Cognitive(7)

Pharmacology

Detection Methods

Standard Drug Panel Inclusion

Urine Detection

Blood and Saliva Detection

Hair Follicle Detection

Confirmatory Testing

Reagent Testing

Interactions

History

Harm Reduction

Toxicity & Safety

Addiction Potential

Overdose Information

Dangerous Interactions

Tolerance

Cross-tolerances

Legal Status

Experience Reports (2)

Tips (7)

Community Discussions (1)

See Also

References (5)

Frequently Asked Questions