moderately addictive with a high potential for abuse

What are the risks of MXiPr?

Extrapolated from MXE MXiPr's toxicity profile is not formally characterized. Based on structural similarity to MXE: Cerebellar toxicity (ataxia, coordination impairment) — a risk shared with MXE Renal toxicity — the kidney damage concern associated with MXE should be applied to MXiPr until evidence

How long does MXiPr last?

The total duration of MXiPr via insufflated is 1.5 hours to 4 hours. Onset typically occurs within 2 minutes to 5 minutes.

MXiPr — SubstanceWiki

MXiPr (methoxetamine isopropyl, or 3-MeO-2'-oxo-PCiPr) is a synthetic dissociative of the arylcyclohexylamine class, a close structural analog of methoxetamine (MXE) in which the N-ethyl group is replaced by a bulkier N-isopropyl group. It represents part of the structural exploration of MXE-derived analogs that emerged following MXE's scheduling — chemists and researchers investigating whether structural variants could recapture MXE's distinctive pharmacological character while existing outside the specific structures covered by legislation.

Like MXE, MXiPr is presumed to act as an NMDA receptor antagonist with possible serotonin reuptake inhibitory activity based on structural similarity. The isopropyl substitution at the nitrogen adds steric bulk compared to MXE's ethyl group, which may alter both the receptor binding profile and pharmacokinetic handling. Whether these differences translate to meaningful experiential differences from MXE is not established from systematic community data.

MXiPr is one of the less well-characterized compounds in the novel dissociative landscape — present in vendor catalogs but without substantial community experience documentation. Harm reduction guidance must be extrapolated from MXE and the broader arylcyclohexylamine class.

How It Feels

The onset is gentle and carries an immediate note of warmth — a physical glow that begins in the chest and expands outward through the torso and into the limbs within fifteen to twenty minutes. It has something of ketamine's familiar signature but friendlier, more inviting, as though ketamine has put on a soft sweater and decided to be kind. The body grows pleasantly heavy, sinking into its surface, and a subtle softening of visual edges suggests that the dissociation is beginning to do its quiet work.

The come-up is where MXiPr distinguishes itself. The warmth intensifies into something genuinely euphoric — not the sharp, stimulant euphoria of the arylcyclohexylamines but a diffuse, serotonergic glow that resembles the entactogenic quality of substances from an entirely different pharmacological family. Sound deepens and enriches; music becomes immersive and emotionally charged, each song acquiring a personal significance that it may not ordinarily possess. Vision begins to shift — colors become more saturated, depth perception subtly alters, and in dim lighting, faint geometric patterns may begin to emerge on surfaces: slow, breathing tessellations that respond to your attention.

At the peak, the dissociation and the visual component merge into something remarkable for a compound in this class. Closed-eye visuals are vivid and colorful: flowing mandalas, spiraling tunnels of light, organic forms that pulse and breathe with your heartbeat. There is a psychedelic quality here that goes well beyond the usual dissociative repertoire — a sense of visual richness that recalls tryptamines more than arylcyclohexylamines. The body is deeply relaxed, almost melted into its surroundings, and the emotional tone is one of quiet awe and gratitude. Music at this point is transcendent, each note arriving with a visual and emotional depth that makes you want to laugh and cry simultaneously.

The duration is moderate — three to four hours at most — and the descent is smooth and even-tempered. The warmth fades gradually, the visuals dim, and the world reasserts its ordinary density without harshness or abruptness. There is a pleasant afterglow that lasts an hour or two: a residual warmth, a lingering appreciation for music and texture, a sense of having been somewhere genuinely beautiful. Sleep comes easily and is restful. MXiPr leaves you the way a good guest leaves a house — with warmth, with gratitude, and with the feeling that you would welcome it back.

Subjective Effects

The effects listed below are based on the Subjective Effect Index (SEI), an open research literature based on anecdotal reports and personal analyses. They should be viewed with a healthy degree of skepticism. These effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects.

Physical Effects

Physical(11)

Body load— A diffuse, heavy physical discomfort involving tension, pressure, and malaise in the torso and limbs...
Dizziness— A sensation of spinning, swaying, or lightheadedness that impairs balance and spatial orientation, o...
Increased heart rate— A noticeable acceleration of heartbeat that can range from a subtle awareness of one's pulse to a fo...
Increased libido— A marked enhancement of sexual desire, arousal, and sensitivity to erotic stimuli that can range fro...
Motor control loss— A distinct decrease in the ability to control one's physical body with precision, balance, and coord...
Nausea— An uncomfortable sensation of queasiness and stomach discomfort that may or may not lead to vomiting...
Pain relief— A suppression of negative physical sensations such as aches and pains, ranging from dulled awareness...
Physical euphoria— An intensely pleasurable bodily sensation that can manifest as waves of warmth, tingling electricity...
Sedation— A state of deep physical and mental calming that manifests as a progressive desire to remain still, ...
Seizure— Uncontrolled brain electrical activity causing convulsions and loss of consciousness -- a life-threa...
Stimulation— A state of heightened physical and mental energy characterized by increased wakefulness, elevated mo...

Tactile(1)

Tactile suppression— A progressive decrease in the ability to feel physical touch, ranging from mild numbness to complete...

Cognitive & Perceptual Effects

Visual(10)

Double vision— The visual experience of seeing a single object as two separate, overlapping images, similar to cros...
Environmental cubism— A visual distortion in which the environment and objects within it appear fragmented into geometric,...
Frame rate suppression— Perception of visual motion as choppy discrete frames rather than smooth continuous flow, resembling...
Geometry— The experience of perceiving complex, ever-shifting geometric patterns superimposed over the visual ...
Internal hallucination— Vivid, detailed visual experiences perceived within an imagined mental landscape that can only be se...
Perspective distortions— Distortion of perceived depth, distance, and size of real objects, making things appear closer, furt...

Interactions

Substance	Status	Note
Acetylfentanyl	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Buprenorphine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Codeine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Desomorphine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Dextropropoxyphene	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Dihydrocodeine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Ethylmorphine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Fentanyl	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Heroin	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Hydrocodone	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Hydromorphone	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Kratom	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Methadone	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Morphine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Naloxone	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
O-Desmethyltramadol	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Oxycodone	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Oxymorphone	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Pethidine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
1,4-Butanediol	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
2-Fluorodeschloroketamine	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
2M2B	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-Cl-PCP	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
3-HO-PCE	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
3-HO-PCP	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
3-MeO-PCE	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
3-MeO-PCMo	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
3-MeO-PCP	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
4-MeO-PCP	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
5F-AKB48	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
5F-PB-22	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
AB-FUBINACA	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Alcohol	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Alprazolam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Anandamide	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
APICA	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Atropa belladonna	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Baclofen	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Benzodiazepines	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Benzydamine	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Cake	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Cannabidiol	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Cannabis	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Carisoprodol	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Clonazepam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Clonazolam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Clonidine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Datura	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Deschloroetizolam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Deschloroketamine	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Dextromethorphan	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Diazepam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Diclazepam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Diphenhydramine	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Diphenidine	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Ephenidine	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Eszopiclone	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Etizolam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
F-Phenibut	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Flualprazolam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Flubromazepam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Flubromazolam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Flunitrazepam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Flunitrazolam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Gabapentin	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Gaboxadol	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
GBL	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
GHB	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Grayanotoxin	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
HXE	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Inhalants	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
JWH-018	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
JWH-073	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Ketamine	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Lorazepam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Memantine	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Mephenaqualone	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Methaqualone	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Methoxetamine	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Methoxphenidine	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Metizolam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Midazolam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Mirtazapine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Myristicin	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Nicotine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Nifoxipam	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Nitrous	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
O-PCE	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
PCE	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
PCP	Caution	Compounding dissociative effects can cause confusion, mania, and loss of motor control
Pentobarbital	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Phenobarbital	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
SAMe	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
1,3-Butanediol	Low Risk & Synergy	Produces unique synergistic effects; often combined
1B-LSD	Low Risk & Synergy	Produces unique synergistic effects; often combined
1cP-AL-LAD	Low Risk & Synergy	Produces unique synergistic effects; often combined
1cP-LSD	Low Risk & Synergy	Produces unique synergistic effects; often combined
1cP-MiPLA	Low Risk & Synergy	Produces unique synergistic effects; often combined
1P-ETH-LAD	Low Risk & Synergy	Produces unique synergistic effects; often combined
1P-LSD	Low Risk & Synergy	Produces unique synergistic effects; often combined
1V-LSD	Low Risk & Synergy	Produces unique synergistic effects; often combined
2,5-DMA	Low Risk & Synergy	Produces unique synergistic effects; often combined
25B-NBOH	Low Risk & Synergy	Produces unique synergistic effects; often combined
25B-NBOMe	Low Risk & Synergy	Produces unique synergistic effects; often combined
25C-NBOH	Low Risk & Synergy	Produces unique synergistic effects; often combined
25C-NBOMe	Low Risk & Synergy	Produces unique synergistic effects; often combined
25D-NBOMe	Low Risk & Synergy	Produces unique synergistic effects; often combined
25E-NBOH	Low Risk & Synergy	Produces unique synergistic effects; often combined
25I-NBOH	Low Risk & Synergy	Produces unique synergistic effects; often combined
25I-NBOMe	Low Risk & Synergy	Produces unique synergistic effects; often combined
25N-NBOMe	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-B	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-B-FLY	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-C	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-D	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-E	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-H	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-I	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-P	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-T	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-T-2	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-T-21	Low Risk & Synergy	Produces unique synergistic effects; often combined
2C-T-7	Low Risk & Synergy	Produces unique synergistic effects; often combined
3C-E	Low Risk & Synergy	Produces unique synergistic effects; often combined
3C-P	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-AcO-DET	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-AcO-DiPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-AcO-DMT	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-AcO-MET	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-AcO-MiPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-HO-DET	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-HO-DiPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-HO-DPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-HO-EPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-HO-MET	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-HO-MiPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
4-HO-MPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
5-MeO-DALT	Low Risk & Synergy	Produces unique synergistic effects; often combined
5-MeO-DiBF	Low Risk & Synergy	Produces unique synergistic effects; often combined
5-MeO-DiPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
5-MeO-DMT	Low Risk & Synergy	Produces unique synergistic effects; often combined
5-MeO-MiPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
6-APB	Low Risk & Synergy	Produces unique synergistic effects; often combined
AL-LAD	Low Risk & Synergy	Produces unique synergistic effects; often combined
ALD-52	Low Risk & Synergy	Produces unique synergistic effects; often combined
Allylescaline	Low Risk & Synergy	Produces unique synergistic effects; often combined
Ayahuasca	Low Risk & Synergy	Produces unique synergistic effects; often combined
Bromo-DragonFLY	Low Risk & Synergy	Produces unique synergistic effects; often combined
Bufotenin	Low Risk & Synergy	Produces unique synergistic effects; often combined
DET	Low Risk & Synergy	Produces unique synergistic effects; often combined
DiPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
DMT	Low Risk & Synergy	Produces unique synergistic effects; often combined
DOB	Low Risk & Synergy	Produces unique synergistic effects; often combined
DOC	Low Risk & Synergy	Produces unique synergistic effects; often combined
DOI	Low Risk & Synergy	Produces unique synergistic effects; often combined
DOM	Low Risk & Synergy	Produces unique synergistic effects; often combined
DPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
Efavirenz	Low Risk & Synergy	Produces unique synergistic effects; often combined
EPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
Escaline	Low Risk & Synergy	Produces unique synergistic effects; often combined
ETH-LAD	Low Risk & Synergy	Produces unique synergistic effects; often combined
Ibogaine	Low Risk & Synergy	Produces unique synergistic effects; often combined
LAE-32	Low Risk & Synergy	Produces unique synergistic effects; often combined
LSA	Low Risk & Synergy	Produces unique synergistic effects; often combined
LSD	Low Risk & Synergy	Produces unique synergistic effects; often combined
LSM-775	Low Risk & Synergy	Produces unique synergistic effects; often combined
LSZ	Low Risk & Synergy	Produces unique synergistic effects; often combined
MDA	Low Risk & Synergy	Produces unique synergistic effects; often combined
Mescaline	Low Risk & Synergy	Produces unique synergistic effects; often combined
MET	Low Risk & Synergy	Produces unique synergistic effects; often combined
Methallylescaline	Low Risk & Synergy	Produces unique synergistic effects; often combined
MiPLA	Low Risk & Synergy	Produces unique synergistic effects; often combined
MiPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
MPT	Low Risk & Synergy	Produces unique synergistic effects; often combined
PARGY-LAD	Low Risk & Synergy	Produces unique synergistic effects; often combined
PRO-LAD	Low Risk & Synergy	Produces unique synergistic effects; often combined
Psilocybin Mushrooms	Low Risk & Synergy	Produces unique synergistic effects; often combined

Dangerous Interactions

The combinations listed below may be life-threatening. Independent research should always be conducted to ensure safety when combining substances.

AcetylfentanylDangerous