LSM-775

LSM-775 (lysergic acid morpholide, also known as N-morpholinyllysergamide) is a synthetic psychedelic of the lysergamide family, structurally distinguished from LSD by the replacement of the diethyl amide group with a morpholine ring. This substitution places a 6-membered oxygen-containing ring at the amide position of the lysergic acid core, significantly altering the steric and electronic properties of the molecule at the amide binding pocket of 5-HT2A receptors.

LSM-775 is less potent than LSD on a microgram-per-microgram basis, with active doses typically reported in the hundreds of micrograms range. Community reports describe the experience as having a somewhat softer, more dreamy quality compared to LSD, with less pronounced stimulation and a character that users frequently describe as more hypnagogic and less cognitively demanding than LSD at comparable effect intensity. Duration is reported as approximately 8–10 hours, similar to LSD.

LSM-775 attracted attention in research chemical communities as one of the relatively rare non-LSD-prodrug lysergamides — unlike most of the 1-acyl series, it is not believed to convert to LSD but rather to act directly in its own right. This makes its receptor pharmacology and subjective character genuinely distinct from LSD rather than simply being a delivery vehicle for it. Community reports are sparse relative to 1P-LSD or LSD, reflecting its more obscure position in the lysergamide landscape.

As with all lysergamides, testing with Ehrlich reagent (purple/violet) is essential before use, and the standard contraindications — personal or family history of psychosis, lithium or MAOI use, cardiovascular disease — apply fully.