What are the effects of Mirtazapine?

At therapeutic doses, mirtazapine's subjective experience is dominated by a profound, almost irresistible sedation. Within thirty to sixty minutes of ingestion, a heavy drowsiness descends like a weighted blanket, pressing consciousness downward with a gentle but relentless force. The eyelids grow i

What are the risks of Mirtazapine?

Mirtazapine is not known to cause brain damage, and has extremely low toxicity relative to dose. Similar to other psychedelic drugs, there are relatively few physical side effects associated with mirtazapine exposure. Various studies have shown that in reasonable doses in a careful context, it prese

How long does Mirtazapine last?

The total duration of Mirtazapine via oral is 14 hours to 24 hours. Onset typically occurs within 15 minutes to 30 minutes. Peak effects last 1.5 hours to 3 hours.

Mirtazapine — SubstanceWiki

Antidepressant medication

Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression. Its effects may take up to four weeks but can also manifest as early as one to two weeks. It is often used in cases of depression complicated by anxiety or insomnia. The effectiveness of mirtazapine is comparable to other commonly prescribed antidepressants. It is taken by mouth.

Common side effects include sleepiness, dizziness, increased appetite, and weight gain. Serious side effects may include mania, low white blood cell count, and increased suicide among children. Withdrawal symptoms may occur when stopping. It is not recommended together with a monoamine oxidase inhibitor, although evidence supporting the danger of this combination has been challenged. It is unclear if use during pregnancy is safe. How it works is not clear, but it may involve blocking certain adrenergic and serotonin receptors. Chemically, it is a tetracyclic antidepressant, and is closely related to mianserin. It also has strong antihistaminergic effects.

Mirtazapine came into medical use in the United States in 1996. The patent expired in 2004, and generic versions are available. In 2023, it was the 99th most commonly prescribed medication in the United States, with more than 6million prescriptions.

Substance	Status	Note
Atropa belladonna	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Cake	Dangerous	Combined CNS depression; risk of respiratory failure
Datura	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Deschloroetizolam	Dangerous	Combined CNS depression; risk of respiratory failure
Desomorphine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Diclazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Diphenhydramine	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Eszopiclone	Dangerous	Combined CNS depression; risk of respiratory failure
Etizolam	Dangerous	Combined CNS depression; risk of respiratory failure
Flubromazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Flubromazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Flunitrazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Flunitrazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Gaboxadol	Dangerous	Combined CNS depression; risk of respiratory failure
Harmala alkaloid	Dangerous	Unpredictable potentiation of CNS depression; risk of respiratory failure
Lorazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Mephenaqualone	Dangerous	Combined CNS depression; risk of respiratory failure
Metizolam	Dangerous	Combined CNS depression; risk of respiratory failure
Midazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Naloxone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Nicotine	Dangerous	Combined CNS depression; risk of respiratory failure
Nifoxipam	Dangerous	Combined CNS depression; risk of respiratory failure
Peganum harmala	Dangerous	Unpredictable potentiation of CNS depression; risk of respiratory failure
Pentobarbital	Dangerous	Combined CNS depression; risk of respiratory failure
Phenobarbital	Dangerous	Combined CNS depression; risk of respiratory failure
SAMe	Dangerous	Combined CNS depression; risk of respiratory failure
1,3-Butanediol	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
25E-NBOH	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
2C-T	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
2C-T-2	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
2C-T-21	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
2C-T-7	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
3-Cl-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-FMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-HO-PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-HO-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MeO-PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MeO-PCMo	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MeO-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
4-MeO-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
4-MMC	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
8-Chlorotheophylline	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Adrafinil	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Allylescaline	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Anandamide	Caution	Increased sedation and cognitive impairment
APICA	Caution	Increased sedation and cognitive impairment
Ayahuasca	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Benzydamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Bromantane	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Cannabidiol	Caution	Increased sedation and cognitive impairment
Deschloroketamine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
DET	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Dichloropane	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Diphenidine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
DiPT	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
DOM	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
DPT	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Efavirenz	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Ephedrine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Ephenidine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
EPT	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Hexedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
HXE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Ibogaine	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Inhalants	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Memantine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
MET	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Methallylescaline	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Methcathinone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MiPT	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
MPT	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
MXiPr	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
O-PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Oxiracetam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Phenylpiracetam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Psilocybin Mushrooms	Caution	Unpredictable compounding of hallucinogenic effects with anticholinergic delirium
Rhodiola Rosea	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other

Full	almost immediately after ingestion
Half	3 days
Zero	7 days

Mirtazapine

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oral

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oral

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