What are the effects of Pentobarbital?

Pentobarbital belongs to an older, more dangerous pharmacological era, and its subjective effects carry an accordingly heavier gravity. Within fifteen to thirty minutes, the onset announces itself as a profound wave of sedation that sweeps through the body with the force of a chemical tide. The musc

What are the risks of Pentobarbital?

Radar plot showing relative physical harm, social harm, and dependence of barbiturates in comparison to other drugs. Pentobarbital likely has moderate toxicity relative to dose. However, pentobarbital is potentially lethal when mixed with depressants like alcohol or opioids. Pentobarbital has a high

How long does Pentobarbital last?

The total duration of Pentobarbital via oral is 4 hours to 6 hours. Onset typically occurs within 15 minutes to 1 hour. Peak effects last 1 hour to 3 hours.

Pentobarbital — SubstanceWiki

Short-acting barbiturate

Pentobarbital (US) or pentobarbitone (British and Australian) is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions in emergencies. It can also be used for short-term treatment of insomnia but has been largely replaced by the benzodiazepine family of drugs.

In high doses, pentobarbital causes death by respiratory arrest. It is frequently used for veterinary euthanasia, and is used by some US states and the United States federal government for executions of convicted criminals by lethal injection. In some countries and states, it is also used for physician-assisted suicide.

Pentobarbital was developed by Ernest H. Volwiler and Donalee L. Tabernde at Abbott Laboratories in 1930. The drug was widely abused beginning in the late 1930s, and it is sometimes known as "yellow jackets" due to the yellow color of Nembutal-branded capsules.

Harm Reduction

It is strongly recommended that one use harm reduction practices when using this drug. -extremely physically and psychologically addictive. Barbiturate withdrawal is medically serious and can potentia...

Read full harm reduction guide

Substance	Status	Note
1,4-Butanediol	Dangerous	Combined CNS depression; risk of respiratory failure
2M2B	Dangerous	Combined CNS depression; risk of respiratory failure
Acetylfentanyl	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Alcohol	Dangerous	Combined CNS depression; risk of respiratory failure
Alprazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Atropa belladonna	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Baclofen	Dangerous	Combined CNS depression; risk of respiratory failure
Benzodiazepines	Dangerous	Combined CNS depression; risk of respiratory failure
Buprenorphine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Cake	Dangerous	Combined CNS depression; risk of respiratory failure
Carisoprodol	Dangerous	Combined CNS depression; risk of respiratory failure
Clonazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Clonazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Clonidine	Dangerous	Combined CNS depression; risk of respiratory failure
Codeine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Datura	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Deschloroetizolam	Dangerous	Combined CNS depression; risk of respiratory failure
Desomorphine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Dextropropoxyphene	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Diazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Diclazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Dihydrocodeine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Diphenhydramine	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Eszopiclone	Dangerous	Combined CNS depression; risk of respiratory failure
Ethylmorphine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Etizolam	Dangerous	Combined CNS depression; risk of respiratory failure
F-Phenibut	Dangerous	Combined CNS depression; risk of respiratory failure
Fentanyl	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Flualprazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Flubromazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Flubromazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Flunitrazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Flunitrazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Gabapentin	Dangerous	Combined CNS depression; risk of respiratory failure
Gaboxadol	Dangerous	Combined CNS depression; risk of respiratory failure
GBL	Dangerous	Combined CNS depression; risk of respiratory failure
GHB	Dangerous	Combined CNS depression; risk of respiratory failure
Grayanotoxin	Dangerous	Combined CNS depression; risk of respiratory failure
Harmala alkaloid	Dangerous	Unpredictable potentiation of CNS depression; risk of respiratory failure
Heroin	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Hydrocodone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Hydromorphone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Kratom	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Lorazepam	Dangerous	Combined CNS depression; risk of respiratory failure
MAOI	Dangerous	Unpredictable potentiation of CNS depression; risk of respiratory failure
Mephenaqualone	Dangerous	Combined CNS depression; risk of respiratory failure
Methadone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Methaqualone	Dangerous	Combined CNS depression; risk of respiratory failure
Metizolam	Dangerous	Combined CNS depression; risk of respiratory failure
Midazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Mirtazapine	Dangerous	Combined CNS depression; risk of respiratory failure
Morphine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Myristicin	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Naloxone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Nicotine	Dangerous	Combined CNS depression; risk of respiratory failure
Nifoxipam	Dangerous	Combined CNS depression; risk of respiratory failure
O-Desmethyltramadol	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Oxycodone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Oxymorphone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Peganum harmala	Dangerous	Unpredictable potentiation of CNS depression; risk of respiratory failure
Pethidine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Phenobarbital	Dangerous	Combined CNS depression; risk of respiratory failure
SAMe	Dangerous	Combined CNS depression; risk of respiratory failure
2-Aminoindane	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2-FA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2-FEA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2-Fluorodeschloroketamine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
2-FMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2,5-DMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2C-H	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-Cl-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-FA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-FEA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-FMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-FPM	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-HO-PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-HO-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MeO-PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MeO-PCMo	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MeO-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MMC	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3,4-CTMP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4-FA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4-FMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4-MeO-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
4-MMC	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4F-EPH	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4F-MPH	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
5-APB	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
5F-AKB48	Caution	Increased sedation and cognitive impairment
5F-PB-22	Caution	Increased sedation and cognitive impairment
6-APDB	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
8-Chlorotheophylline	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
A-PHP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
A-PVP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
AB-FUBINACA	Caution	Increased sedation and cognitive impairment
Adrafinil	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Amphetamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Anandamide	Caution	Increased sedation and cognitive impairment
APICA	Caution	Increased sedation and cognitive impairment
Armodafinil	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Benzydamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Bromantane	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Butylone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Caffeine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Cannabidiol	Caution	Increased sedation and cognitive impairment
Cannabis	Caution	Increased sedation and cognitive impairment
Cocaine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Cyclazodone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Deschloroketamine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Desoxypipradrol	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Dextroamphetamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Dextromethorphan	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Dichloropane	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Diphenidine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Ephedrine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Ephenidine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Ephylone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
ETH-CAT	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Ethylone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Ethylphenidate	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Fenethylline	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Hexedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
HXE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Inhalants	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Isopropylphenidate	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
JWH-018	Caution	Increased sedation and cognitive impairment
JWH-073	Caution	Increased sedation and cognitive impairment
Ketamine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Lisdexamfetamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MCPP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MDA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MDMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MDPV	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Memantine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Mephedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methamphetamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methcathinone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methiopropamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methoxetamine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Methoxphenidine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Methylnaphthidate	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methylone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methylphenidate	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Mexedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Modafinil	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MXiPr	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
N-Ethylhexedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
N-Methylbisfluoromodafinil	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
NEP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Nitrous	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
NM-2-AI	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
O-PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Oxiracetam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Pentedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Phenylpiracetam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Rhodiola Rosea	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2C-B	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers
DMT	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers
LSD	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers
Mescaline	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers
Psilocybin Mushrooms	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers

Full	Unknown
Half	Unknown
Zero	Unknown

Pentobarbital

Quick Dosage

Dosage

oral

Duration

oral

How It Feels

Subjective Effects

Physical Effects

Physical(9)

Cognitive & Perceptual Effects

Cognitive(11)

Pharmacology

Detection Methods

Standard Drug Panel Inclusion

Urine Detection

Blood and Serum Detection

Hair Follicle Detection

Confirmatory Methods

Reagent Testing

Interactions

History

Harm Reduction

Toxicity & Safety

Addiction Potential

Overdose Information

Dangerous Interactions

Tolerance

Legal Status

Experience Reports (2)

Tips (3)

See Also

References (4)

Frequently Asked Questions