How long does Flunitrazolam last?

The total duration of Flunitrazolam via oral is 4 hours to 8 hours. Onset typically occurs within 20 minutes to 40 minutes. Peak effects last 1 hour to 2 hours.

Flunitrazolam — SubstanceWiki

Triazolobenzodiazepine drug

Flunitrazolam (FNTZ, Flunazolam) is a triazolobenzodiazepine (TBZD), which are benzodiazepine (BZD) derivatives, that has been sold online as a designer drug, and is a potent hypnotic and sedative drug similar to related compounds such as flunitrazepam, clonazolam and flubromazolam. It was first definitively identified and reported to the EMCDDA Early Warning System, by an analytical laboratory in Germany in October 2016, and had not been described in the scientific or patent literature before this. It is the triazole analogue of Flunitrazepam (Rohypnol). The addition of the triazole ring to the scaffold increases potency significantly, this is evident as flunitrazolam is reported anecdotally to be active in the microgram level. It is active at 0.1mg.

Harm Reduction

How It Feels

Flunitrazolam operates on a compressed timeline, its effects arriving with the urgency of a substance that knows it will not be staying long. Within ten to fifteen minutes, the sedation hits like a soft hammer -- a sudden, enveloping heaviness that pulls consciousness downward. The anxiety vanishes instantly, as though a switch had been thrown, and the muscles relax with a speed and completeness that can feel like falling. The world contracts to the immediate: the warmth of the body, the softness of the surface beneath you, the fading edges of the visual field.

The come-up is brief and intense. Within twenty minutes of onset, the full effects are already establishing themselves with a thoroughness that leaves little room for nuance. The sedation is heavy, the muscle relaxation complete, and the amnestic properties begin to assert themselves almost immediately. Thoughts become slippery, difficult to hold on to, each one dissolving before it can be fully formed. There is a dreamlike quality to perception -- the visual world seems to shimmer and shift, edges softening, colors muting, as though reality were being observed through frosted glass. Speech becomes effortful and imprecise, and the motivation to speak diminishes rapidly.

At the peak, the experience collapses into a narrow window of heavy sedation and near-total amnesia. This is the defining characteristic of flunitrazolam: its ability to erase the experience of itself as it unfolds. The body is warm and motionless, the mind a quiet void that registers comfort without recording details. Time becomes meaningless in the most literal sense -- not distorted or slowed, but simply untracked, its passage leaving no marks. The peak is paradoxically both the most intense and least memorable phase of the experience. What euphoria exists is experienced in the moment and forgotten immediately, like words written in water.

The offset is abrupt relative to longer-acting benzodiazepines. Within three to four hours, the worst of the sedation lifts, though a residual grogginess and confusion may persist. Waking from the experience -- whether from actual sleep or from the semi-conscious state that the peak resembles -- brings a disorientation and a profound sense of missing time. The gaps in memory are clean-edged and complete, as though pages had been torn from a diary.

Pharmacology

Benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of flunitrazolam on the nervous system.

The anticonvulsant properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.

Experimental results for Flunitrazolam often yield findings of sedation, disinhibition, dream potentiation, residual sleepiness, thought deceleration, and muscle relaxation.

Flunitrazolam has distinct effects which range from barely noticeable to complete memory loss, depending strongly on dosage and physical differences in metabolism. It shares some common traits among many users, including mild or threshold effects at lower dosage levels before quickly turning into very amnesic or black-out states over a certain dosage (some people report 300 mg). It predominantly has hypnotic effects and notable muscle relaxation, while lacking anxiety suppression or sedating effects.

Volumetric liquid dosing** - If one's benzodiazepines are in powder form, they are unlikely to weigh out accurately without the most expensive of scales due to their extreme potency. To avoid this, one can dissolve the benzodiazepine volumetrically into a solution and dose it accurately based upon the instructions linked within this tutorial.

Due to Flunitrazolam's extreme potency compared to even other ultrapotent benzodiazepines it should be used even more carefully when making and using a volumetric liquid solution. One should weigh at least 30mgs or Flunitrazolam which requires a bit bigger dropper bottles. The bottle should be shaked everytime before usage.

low toxicity relative to dose. However, it is lethal when mixed with depressants like alcohol or opioids]].

It is strongly recommended that one use harm reduction practices when using this substance. -extremely physically and psychologically addictive.

Tolerance will develop to the sedative-within a couple of days of continuous use. After cessation,7 - 14 days. However, in certain cases this may take significantly longer in a manner which is proportional to the duration and intensity of one's long-term usage.

Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction. For more information on tapering from benzodiazepines in a controlled manner, please see this guide.

Benzodiazepine discontinuation is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of hypertension, seizures, and death..

Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly. Symptoms of a benzodiazepine overdose may include severe thought deceleration, slurred speech, confusion, delusions, respiratory depression, coma or death. Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. Benzodiazepine overdoses are sometimes treated with flumazenil, a GABAA antagonist, however care is primarily supportive in nature.

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Depressants** (1,4-Butanediol, 2-methyl-2-butanol, alcohol, barbiturates, GHB/GBL, methaqualone, opioids) - This combination can result in dangerous or even fatal levels of respiratory depression. These substances potentiate the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation ("pulmonary aspiration"). If extreme sleepiness or loss of consciousness occur, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Dissociatives** - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Stimulants** - It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants mask the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects. If combined, one should strictly limit themselves to only dosing a certain amount of benzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.

Flunitrazolam is currently a gray area compound within most (if not all) parts of the world. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.

Switzerland:** Flunitrazolam is legal in Switzerland as of September 2021.
Responsible use
Depressants
Flunitrazepam
Flubromazepam
Benzodiazepines
Flunitrazolam (Wikipedia)
Flunitrazolam (Isomer Design)

Detection Methods

Standard Drug Panel Inclusion

Flunitrazolam is NOT detected on standard drug panels. This ultra-potent designer benzodiazepine, pharmacologically active at doses as low as 0.1 mg, has structural modifications that prevent recognition by conventional immunoassay antibodies. Standard benzodiazepine screens consistently return false-negative results. The triazolobenzodiazepine structure combined with the nitro group creates a compound that falls outside the detection range of most commercial screening platforms.

Urine Detection

Flunitrazolam and its metabolites are detectable in urine for approximately 2 to 5 days after a single dose. The primary metabolic pathway involves nitroreduction to 7-aminoflunitrazolam, followed by hydroxylation and glucuronidation. The extremely low doses consumed result in very low urinary metabolite concentrations, often requiring ultra-sensitive LC-MS/MS methods with limits of detection below 1 ng/mL. Standard urine drug screening panels do not include this compound.

Blood and Serum Detection

Blood detection windows are 1 to 2 days. Active blood concentrations are in the sub-nanogram to low nanogram range, reflecting the extreme potency. Forensic blood analysis requires highly sensitive LC-MS/MS methods. Published case reports document blood concentrations associated with impairment or overdose below 5 ng/mL.

Hair Follicle Detection

Hair detection is extremely challenging due to the ultra-low doses consumed. Few forensic laboratories have validated methods for flunitrazolam in hair, and detection limits well below 1 pg/mg are required.

Confirmatory Methods

LC-MS/MS with high sensitivity is required for confirmation. The compound must be explicitly added to designer benzodiazepine panels. Reference standards are available but must be specifically requested. The metabolite 7-aminoflunitrazolam is the primary urinary biomarker targeted in published forensic methods.

Reagent Testing

Reagent testing is impractical for flunitrazolam due to the sub-milligram doses involved. No visible colorimetric reaction is achievable at typical dose quantities. Fentanyl test strips are critically important for any product suspected to contain this compound.

Interactions

Substance	Status	Note
1,4-Butanediol	Dangerous	Combined CNS depression; risk of respiratory failure
2M2B	Dangerous	Combined CNS depression; risk of respiratory failure
Acetylfentanyl	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Alcohol	Dangerous	Combined CNS depression; risk of respiratory failure
Alprazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Atropa belladonna	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Baclofen	Dangerous	Combined CNS depression; risk of respiratory failure
Benzodiazepines	Dangerous	Combined CNS depression; risk of respiratory failure
Buprenorphine	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Cake	Dangerous	Combined CNS depression; risk of respiratory failure
Carisoprodol	Dangerous	Combined CNS depression; risk of respiratory failure
Clonazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Clonazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Clonidine	Dangerous	Combined CNS depression; risk of respiratory failure
Codeine	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Datura	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Deschloroetizolam	Dangerous	Combined CNS depression; risk of respiratory failure
Desomorphine	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Dextropropoxyphene	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Diazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Diclazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Dihydrocodeine	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Diphenhydramine	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Eszopiclone	Dangerous	Combined CNS depression; risk of respiratory failure
Ethylmorphine	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Etizolam	Dangerous	Combined CNS depression; risk of respiratory failure
F-Phenibut	Dangerous	Combined CNS depression; risk of respiratory failure
Fentanyl	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Flualprazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Flubromazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Flubromazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Flunitrazepam	Dangerous	Combined CNS depression; risk of respiratory failure
Gabapentin	Dangerous	Combined CNS depression; risk of respiratory failure
Gaboxadol	Dangerous	Combined CNS depression; risk of respiratory failure
GBL	Dangerous	Combined CNS depression; risk of respiratory failure
GHB	Dangerous	Combined CNS depression; risk of respiratory failure
Grayanotoxin	Dangerous	Combined CNS depression; risk of respiratory failure
Harmala alkaloid	Dangerous	Unpredictable potentiation of CNS depression; risk of respiratory failure
Heroin	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Hydrocodone	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Hydromorphone	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Kratom	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Lorazepam	Dangerous	Combined CNS depression; risk of respiratory failure
MAOI	Dangerous	Unpredictable potentiation of CNS depression; risk of respiratory failure
Mephenaqualone	Dangerous	Combined CNS depression; risk of respiratory failure
Methadone	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Methaqualone	Dangerous	Combined CNS depression; risk of respiratory failure
Metizolam	Dangerous	Combined CNS depression; risk of respiratory failure
Midazolam	Dangerous	Combined CNS depression; risk of respiratory failure
Mirtazapine	Dangerous	Combined CNS depression; risk of respiratory failure
Morphine	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Myristicin	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Naloxone	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Nicotine	Dangerous	Combined CNS depression; risk of respiratory failure
Nifoxipam	Dangerous	Combined CNS depression; risk of respiratory failure
O-Desmethyltramadol	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Oxycodone	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Oxymorphone	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Peganum harmala	Dangerous	Unpredictable potentiation of CNS depression; risk of respiratory failure
Pentobarbital	Dangerous	Combined CNS depression; risk of respiratory failure
Pethidine	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Phenobarbital	Dangerous	Combined CNS depression; risk of respiratory failure
SAMe	Dangerous	Combined CNS depression; risk of respiratory failure
2-Aminoindane	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2-FA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2-FEA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2-Fluorodeschloroketamine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
2-FMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2,5-DMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2C-H	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-Cl-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-FA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-FEA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-FMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-FPM	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3-HO-PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-HO-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MeO-PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MeO-PCMo	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MeO-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
3-MMC	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
3,4-CTMP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4-FA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4-FMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4-MeO-PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
4-MMC	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4F-EPH	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
4F-MPH	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
5-APB	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
5F-AKB48	Caution	Increased sedation and cognitive impairment
5F-PB-22	Caution	Increased sedation and cognitive impairment
6-APDB	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
8-Chlorotheophylline	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
A-PHP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
A-PVP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
AB-FUBINACA	Caution	Increased sedation and cognitive impairment
Adrafinil	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Amphetamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Anandamide	Caution	Increased sedation and cognitive impairment
APICA	Caution	Increased sedation and cognitive impairment
Armodafinil	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Benzydamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Bromantane	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Butylone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Caffeine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Cannabidiol	Caution	Increased sedation and cognitive impairment
Cannabis	Caution	Increased sedation and cognitive impairment
Cocaine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Cyclazodone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Deschloroketamine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Desoxypipradrol	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Dextroamphetamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Dextromethorphan	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Dichloropane	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Diphenidine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Ephedrine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Ephenidine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Ephylone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
ETH-CAT	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Ethylone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Ethylphenidate	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Fenethylline	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Hexedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
HXE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Inhalants	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Isopropylphenidate	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
JWH-018	Caution	Increased sedation and cognitive impairment
JWH-073	Caution	Increased sedation and cognitive impairment
Ketamine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Lisdexamfetamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MCPP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MDA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MDMA	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MDPV	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Memantine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Mephedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methamphetamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methcathinone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methiopropamine	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methoxetamine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Methoxphenidine	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Methylnaphthidate	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methylone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Methylphenidate	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Mexedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Modafinil	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
MXiPr	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
N-Ethylhexedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
N-Methylbisfluoromodafinil	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
NEP	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Nitrous	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
NM-2-AI	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
O-PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Oxiracetam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
PCE	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
PCP	Caution	Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression
Pentedrone	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Phenylpiracetam	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
Rhodiola Rosea	Caution	Masks the effects of each drug; risk of overdosing when one wears off before the other
2C-B	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers
DMT	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers
LSD	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers
Mescaline	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers
Psilocybin Mushrooms	Low Risk & Decrease	Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers

Showing 164 key interactions out of 240 total.

Toxicity & Safety

Radar plot showing relative physical harm, social harm, and dependence of benzodiazepines in comparison to other drugs. Further information: Research chemicals § Toxicity and harm potential Flunitrazolam likely has a low toxicity relative to dose. However, it is potentially lethal when mixed with depressants like alcohol or opioids.

It is strongly recommended that one use harm reduction practices when using this substance.

Dependence and abuse potential

Flunitrazolam is extremely physically and psychologically addictive.

Tolerance will develop to the sedative-hypnotic effects within a couple of days of continuous use. After cessation, the tolerance returns to baseline in 7 - 14 days. However, in certain cases this may take significantly longer in a manner which is proportional to the duration and intensity of one's long-term usage.

Flunitrazolam presents cross-tolerance with all benzodiazepines, meaning that after its consumption all benzodiazepines will have a reduced effect.

Overdose

Benzodiazepine overdose may occur when a benzodiazepine is taken in extremely heavy quantities or concurrently with other depressants. This is particularly dangerous with other GABAergic depressants such as barbiturates and alcohol since they work in a similar fashion, but bind to distinct allosteric sites on the GABAA receptor. Thus, their effects potentiate one another. Benzodiazepines increase the frequency in which the chlorine ion pore opens on the GABAA receptor while barbiturates increase the duration in which they are open, meaning when both are consumed, the ion pore will open more frequently and stay open longer.

Dangerous interactions

Depressants (1,4-Butanediol, 2-methyl-2-butanol, alcohol, barbiturates, GHB/GBL, methaqualone, opioids) - This combination can result in dangerous or even fatal levels of respiratory depression. These substances potentiate the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation ("pulmonary aspiration"). If extreme sleepiness or loss of consciousness occur, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Dissociatives - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Stimulants - It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants mask the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects. If combined, one should strictly limit themselves to only dosing a certain amount of benzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.

Addiction Potential

extremely physically and psychologically addictive

Overdose Information

overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly. Symptoms of a benzodiazepine overdose may include severe thought deceleration, slurred speech, confusion, delusions, respiratory depression, coma or death. Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. Benzodiazepine overdoses are sometimes treated with flumazenil, a GABAA antagonist, however care is primarily supportive in nature.

Depressants** (1,4-Butanediol, 2-methyl-2-butanol, alcohol, barbiturates, GHB/GBL, methaqualone, opioids) - This combination can result in dangerous or even fatal levels of respiratory depression. These substances potentiate the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation ("pulmonary aspiration"). If extreme sleepiness or loss of consciousness occur, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Dissociatives** - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Stimulants** - It is dangerous to combine benzodiazepines with stimulants due to t

Dangerous Interactions

The combinations listed below may be life-threatening. Independent research should always be conducted to ensure safety when combining substances.

1,4-ButanediolDangerous

Combined CNS depression; risk of respiratory failure

2M2BDangerous

Combined CNS depression; risk of respiratory failure

AcetylfentanylDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

AlcoholDangerous

Combined CNS depression; risk of respiratory failure

AlprazolamDangerous

Combined CNS depression; risk of respiratory failure

Atropa belladonnaDangerous

Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure

BaclofenDangerous

Combined CNS depression; risk of respiratory failure

BenzodiazepinesDangerous

Combined CNS depression; risk of respiratory failure

BuprenorphineDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

CakeDangerous

Combined CNS depression; risk of respiratory failure

CarisoprodolDangerous

Combined CNS depression; risk of respiratory failure

ClonazepamDangerous

Combined CNS depression; risk of respiratory failure

ClonazolamDangerous

Combined CNS depression; risk of respiratory failure

ClonidineDangerous

Combined CNS depression; risk of respiratory failure

CodeineDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

DaturaDangerous

Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure

DeschloroetizolamDangerous

Combined CNS depression; risk of respiratory failure

DesomorphineDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

DextropropoxypheneDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

DiazepamDangerous

Combined CNS depression; risk of respiratory failure

DiclazepamDangerous

Combined CNS depression; risk of respiratory failure

DihydrocodeineDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

DiphenhydramineDangerous

Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure

EszopicloneDangerous

Combined CNS depression; risk of respiratory failure

EthylmorphineDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

EtizolamDangerous

Combined CNS depression; risk of respiratory failure

F-PhenibutDangerous

Combined CNS depression; risk of respiratory failure

FentanylDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

FlualprazolamDangerous

Combined CNS depression; risk of respiratory failure

FlubromazepamDangerous

Combined CNS depression; risk of respiratory failure

FlubromazolamDangerous

Combined CNS depression; risk of respiratory failure

FlunitrazepamDangerous

Combined CNS depression; risk of respiratory failure

GabapentinDangerous

Combined CNS depression; risk of respiratory failure

GaboxadolDangerous

Combined CNS depression; risk of respiratory failure

GBLDangerous

Combined CNS depression; risk of respiratory failure

GHBDangerous

Combined CNS depression; risk of respiratory failure

GrayanotoxinDangerous

Combined CNS depression; risk of respiratory failure

Harmala alkaloidDangerous

Unpredictable potentiation of CNS depression; risk of respiratory failure

HeroinDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

HydrocodoneDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

HydromorphoneDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

KratomDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

LorazepamDangerous

Combined CNS depression; risk of respiratory failure

MAOIDangerous

Unpredictable potentiation of CNS depression; risk of respiratory failure

MephenaqualoneDangerous

Combined CNS depression; risk of respiratory failure

MethadoneDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

MethaqualoneDangerous

Combined CNS depression; risk of respiratory failure

MetizolamDangerous

Combined CNS depression; risk of respiratory failure

MidazolamDangerous

Combined CNS depression; risk of respiratory failure

MirtazapineDangerous

Combined CNS depression; risk of respiratory failure

MorphineDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

MyristicinDangerous

Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure

NaloxoneDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

NicotineDangerous

Combined CNS depression; risk of respiratory failure

NifoxipamDangerous

Combined CNS depression; risk of respiratory failure

O-DesmethyltramadolDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

OxycodoneDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

OxymorphoneDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

Peganum harmalaDangerous

Unpredictable potentiation of CNS depression; risk of respiratory failure

PentobarbitalDangerous

Combined CNS depression; risk of respiratory failure

PethidineDangerous

Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths

PhenobarbitalDangerous

Combined CNS depression; risk of respiratory failure

SAMeDangerous

Combined CNS depression; risk of respiratory failure

Full	within a couple of days of continuous use
Half	Unknown
Zero	7 - 14 days

Flunitrazolam

Quick Dosage

Dosage

oral

Duration

oral

How It Feels

Subjective Effects

Physical Effects

Physical(5)

Cognitive & Perceptual Effects

Cognitive(9)

Pharmacology

Detection Methods

Standard Drug Panel Inclusion

Urine Detection

Blood and Serum Detection

Hair Follicle Detection

Confirmatory Methods

Reagent Testing

Interactions

History

Harm Reduction

Toxicity & Safety

Addiction Potential

Overdose Information

Dangerous Interactions

Tolerance

Cross-tolerances

Legal Status

Experience Reports (2)

Tips (8)

Community Discussions (2)

See Also

References (4)

Frequently Asked Questions