How long does 5F-PB-22 last?

The total duration of 5F-PB-22 via oral is 2 hours to 3 hours.

5F-PB-22 — SubstanceWiki

5F-PB-22 (quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate) is a synthetic cannabinoid receptor agonist in the indolecarboxylate (ester) class. It is the 5-fluoro derivative of PB-22, characterized by a quinoline head group connected via an ester linkage to an indole core with a fluorinated pentyl chain. The ester linkage is pharmacologically significant: it is hydrolyzable by tissue esterases, potentially releasing active fragments in vivo and contributing to both the pharmacological activity and metabolic profile distinct from amide-linked synthetic cannabinoids.

5F-PB-22 is a potent full agonist at CB1 and CB2 receptors. Like other fluorinated synthetic cannabinoids, it was developed in part to evade regulatory scheduling of its non-fluorinated parent. It has been associated with multiple serious adverse events, deaths, and mass poisoning incidents. The quinoline head group and ester linkage distinguish its chemistry from the indazole and adamantyl compounds, but the toxicological profile — dominated by full CB1 agonism — is similar.

Harm Reduction

No Safe Use Pattern The lack of a pharmacological ceiling, dose uncertainty from product contamination, and documented mass fatality events collectively mean that no dosing pattern eliminates the risk...

How It Feels

5F-PB-22 wraps itself around consciousness like a warm, synthetic fog. The onset after inhalation is rapid -- within one to five minutes -- and it arrives with a heaviness that is immediately more sedating than most natural cannabis strains. A warmth blooms in the chest and radiates outward, carrying with it a thick, cottony drowsiness that settles over the mind like a heavy curtain. The eyes grow heavy. The body sinks.

At the peak, the sedation is the dominant feature. The body becomes profoundly heavy, each limb weighted with a gravitational pull that makes movement feel like an enormous effort. The mind slows to a crawl, thoughts arriving with the sluggish pace of honey dripping from a spoon. There is a warmth to the experience that is genuinely pleasant -- a full-body glow that resembles an amplified version of the most sedating indica strains. But beneath the warmth, there is a synthetic edge that cannot quite be ignored: a faint chemical taste in the mouth, a slight pressure behind the eyes, a quality to the intoxication that feels manufactured rather than grown.

Time distortion is significant. Minutes stretch into vast, empty intervals where very little happens but everything feels consequential. The emotional tone is flat rather than euphoric -- there is neither particular joy nor particular sadness, just a vast, warm indifference that makes the world's demands feel irrelevant. Short-term memory is severely compromised, conversations and thoughts evaporating almost as quickly as they form. You may find yourself staring at a single point for extended periods, not lost in thought exactly but lost in the absence of thought, consciousness reduced to a warm, empty hum.

The body responds with heavy eyelids, dry mouth, and a hunger that can surface with surprising intensity despite the general immobility. The heart rate may elevate, though the sedation often masks the awareness of it. Coordination is significantly impaired -- walking feels uncertain, handling objects becomes clumsy, and the disconnect between intention and execution widens into a noticeable gap.

The duration of primary effects is one to two hours, though the residual sedation can persist for considerably longer, leaving a drowsy, foggy aftermath that gradually clears over the course of several hours. The comedown is smooth relative to some synthetic cannabinoids, lacking the sharp anxiety or headache that characterize harsher compounds. What remains is a heavy-limbed tiredness, a cotton mouth, and a vague hunger that is best addressed before sleep overtakes the will to eat.

Subjective Effects

The effects listed below are based on the Subjective Effect Index (SEI), an open research literature based on anecdotal reports and personal analyses. They should be viewed with a healthy degree of skepticism. These effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects.

Physical Effects

Physical(12)

Appetite enhancement— A distinct increase in hunger and desire for food, often accompanied by enhanced enjoyment of taste ...
Dehydration— A state of insufficient bodily hydration manifesting as persistent thirst, dry mouth, and physical d...
Dizziness— A sensation of spinning, swaying, or lightheadedness that impairs balance and spatial orientation, o...
Dry mouth— A persistent, uncomfortable reduction in saliva production causing the mouth and throat to feel parc...
Headache— A painful sensation of pressure, throbbing, or aching in the head that can range from a dull backgro...
Increased heart rate— A noticeable acceleration of heartbeat that can range from a subtle awareness of one's pulse to a fo...
Motor control loss— A distinct decrease in the ability to control one's physical body with precision, balance, and coord...
Nausea— An uncomfortable sensation of queasiness and stomach discomfort that may or may not lead to vomiting...
Pain relief— A suppression of negative physical sensations such as aches and pains, ranging from dulled awareness...
Physical euphoria— An intensely pleasurable bodily sensation that can manifest as waves of warmth, tingling electricity...
Sedation— A state of deep physical and mental calming that manifests as a progressive desire to remain still, ...
Stimulation— A state of heightened physical and mental energy characterized by increased wakefulness, elevated mo...

Cognitive & Perceptual Effects

Visual(2)

Colour enhancement— An intensification of the brightness, vividness, and saturation of colors in the external environmen...
Geometry— The experience of perceiving complex, ever-shifting geometric patterns superimposed over the visual ...

Cognitive(7)

Anxiety— Intense feelings of apprehension, worry, and dread that can range from a subtle background unease to...
Conceptual thinking

Detection Methods

Standard Drug Panel Inclusion

5F-PB-22 is a synthetic cannabinoid receptor agonist that is not detected on standard 5-panel drug screens. Standard THC immunoassays target 11-nor-9-carboxy-THC (THC-COOH), the primary metabolite of delta-9-THC, and do not cross-react with synthetic cannabinoids. Some expanded drug panels (12-panel or custom panels) include a synthetic cannabinoid channel, but coverage of specific compounds varies widely between manufacturers.

Urine Detection

5F-PB-22 and its metabolites can be detected in urine for approximately 2 to 5 days after a single use, though chronic heavy use can extend this window to 7 or more days. Synthetic cannabinoids undergo extensive hepatic metabolism, primarily via hydroxylation and carboxylation, producing metabolites that are excreted in urine as glucuronide conjugates. The specific metabolite profile varies by compound and is a key factor in whether a given immunoassay can detect 5F-PB-22.

Blood and Saliva Detection

Blood concentrations of 5F-PB-22 decline rapidly after use, with a detection window of approximately 12 to 48 hours for the parent compound. Metabolites may persist longer. Oral fluid testing can detect parent compound and early metabolites for approximately 24 to 48 hours, and some roadside testing devices include synthetic cannabinoid panels.

Hair Follicle Detection

Hair follicle analysis can detect synthetic cannabinoids for up to 90 days. However, incorporation rates and detectability vary by compound. Some laboratories offer expanded hair panels that include common synthetic cannabinoids such as JWH-018 and AB-FUBINACA metabolites, but coverage of newer compounds including 5F-PB-22 may be limited.

Confirmatory Testing

LC-MS/MS is the preferred confirmatory method for synthetic cannabinoids. The structural diversity and rapid evolution of this substance class means that reference standards must be available for the specific compound under investigation. GC-MS can also be used but LC-MS/MS offers superior sensitivity and specificity for the typically low concentrations encountered. Both parent compound and key metabolites should be targeted.

Reagent Testing

Standard reagent tests (Marquis, Mecke, Mandelin) are generally uninformative for synthetic cannabinoids, as these compounds are typically applied to herbal material at very low concentrations and produce no characteristic color reactions. Visual inspection and reagent testing cannot distinguish treated herbal material from untreated plant matter. Immunoassay-based test strips specific to synthetic cannabinoids are available from some harm reduction suppliers and represent a more practical point-of-use screening option.

Interactions

Substance	Status	Note
1,3-Butanediol	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
25E-NBOH	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
2C-T	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
2C-T-2	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
2C-T-21	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
2C-T-7	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
3-Cl-PCP	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
3-HO-PCE	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
3-HO-PCP	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
3-MeO-PCE	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
3-MeO-PCMo	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
3-MeO-PCP	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
4-MeO-PCP	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Allylescaline	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
Ayahuasca	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
Cake	Caution	Increased sedation and cognitive impairment
Deschloroetizolam	Caution	Increased sedation and cognitive impairment
Deschloroketamine	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
DET	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
Diclazepam	Caution	Increased sedation and cognitive impairment
Diphenidine	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
DiPT	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
DOM	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
DPT	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
Efavirenz	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
Ephenidine	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
EPT	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
Eszopiclone	Caution	Increased sedation and cognitive impairment
Etizolam	Caution	Increased sedation and cognitive impairment
Flubromazepam	Caution	Increased sedation and cognitive impairment
Flubromazolam	Caution	Increased sedation and cognitive impairment
Flunitrazepam	Caution	Increased sedation and cognitive impairment
Flunitrazolam	Caution	Increased sedation and cognitive impairment
Gaboxadol	Caution	Increased sedation and cognitive impairment
HXE	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Ibogaine	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
Inhalants	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Lorazepam	Caution	Increased sedation and cognitive impairment
Memantine	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Mephenaqualone	Caution	Increased sedation and cognitive impairment
MET	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
Methallylescaline	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
Metizolam	Caution	Increased sedation and cognitive impairment
Midazolam	Caution	Increased sedation and cognitive impairment
MiPT	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
MPT	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
MXiPr	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Nicotine	Caution	Increased sedation and cognitive impairment
Nifoxipam	Caution	Increased sedation and cognitive impairment
O-PCE	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
PCE	Caution	Cannabis can intensify dissociation and increase confusion and disorientation
Pentobarbital	Caution	Increased sedation and cognitive impairment
Phenobarbital	Caution	Increased sedation and cognitive impairment
Psilocybin Mushrooms	Caution	Cannabis can unpredictably intensify psychedelic effects and increase anxiety
SAMe	Caution	Increased sedation and cognitive impairment
Cocaine	Uncertain	—
DMT	Uncertain	—
LSD	Uncertain	—
Mescaline	Uncertain	—

Showing 59 key interactions out of 63 total.

Toxicity & Safety

Documented Severe Toxicity

5F-PB-22 has been linked to confirmed fatalities and severe adverse events. Emergency and forensic reports document cardiovascular failure, seizures, renal failure, and acute psychotic episodes. Mass poisoning events involving products containing 5F-PB-22 have been reported in public health literature.

Cardiovascular and Renal Events

The full agonist profile at cardiac CB1 receptors, combined with the altered metabolic profile of the ester-linked compound, contributes to the cardiovascular toxicity profile. Renal failure cases — which are not associated with THC and appear to be a specific synthetic cannabinoid toxicity — have been attributed to 5F-PB-22 in toxicological analyses.

Psychiatric Toxicity

Acute psychosis requiring psychiatric hospitalization has been attributed to 5F-PB-22 use in multiple case reports. The quinoline fragment generated by ester hydrolysis may contribute pharmacological effects distinct from CB1 agonism.

Addiction Potential

moderately addictive with a high potential for abuse

Overdose Information

overdose will cause physical discomfort including heart palpitations, vertigo and sedation at much lower than dangerous doses, usually causing the user to suffer large amounts of anxiety or to fall asleep.

There have been many hospital reports involving 5F-PB-22, as well as cases of post-mortem analysis involving 5F-PB-22. Five deaths have been associated with the use of 5F-PB-22 in the United States., particularly in vulnerable individuals with risk factors for psychotic illnesses (like a past or family history of schizophrenia).

Germany: 5F-PB-22 is controlled under Anlage II BtMG (Narcotics Act, Schedule II) as of December 13, 2014. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
Latvia: 5F-PB-22 is a Schedule I controlled substance.
Switzerland: 5F-PB-22 is a controlled substance specifically named under Verzeichnis D.
United Kingdom: 5F-PB-22 is a Class B controlled substance under the third-generation synthetic cannabinoids generic definition, which came into effect on December 14, 2016 and is illegal to possess, produce, supply, or import.
United States: In January 2014, 5F-PB-22 was designated as a Schedule I controlled substance in the United States.
Responsible use
JWH-018
THJ-018
5F-AKB48
Synthetic cannabinoid
Cannabis
5F-PB-22 (Wikipedia)
5F-PB-22 (Isomer Design)

Full	develops with prolonged and repeated use
Half	3 - 7 days
Zero	1 - 2 weeks

5F-PB-22

Quick Dosage

Dosage

oral

smoked

Duration

How It Feels

Subjective Effects

Physical Effects

Physical(12)

Cognitive & Perceptual Effects

Visual(2)

Cognitive(7)

Pharmacology

Mechanism of Action

Ester Linkage and Metabolism

Fluorination Effects

Detection Methods

Standard Drug Panel Inclusion

Urine Detection

Blood and Saliva Detection

Hair Follicle Detection

Confirmatory Testing

Reagent Testing

Interactions

History

Development and Market Entry

Scheduling

Forensic Significance

Harm Reduction

No Safe Use Pattern

Emergency Indicators

Basic Precautions If Use Continues

Toxicity & Safety

Documented Severe Toxicity

Cardiovascular and Renal Events

Psychiatric Toxicity

Addiction Potential

Overdose Information

Tolerance

Cross-tolerances

Legal Status

Experience Reports (2)

Tips (4)

See Also

References (4)

Frequently Asked Questions