What are the effects of Dextropropoxyphene?

Dextropropoxyphene is an opioid of modest ambitions. Its onset unfolds over forty-five minutes to an hour, arriving not with any particular fanfare but with a quiet, almost apologetic warmth that settles into the body like a lukewarm bath. The first signs are easy to miss: a faint relaxation in the

Is Dextropropoxyphene addictive?

moderately addictive with a high potential for abuse

What are the risks of Dextropropoxyphene?

Dextropropoxyphene has a high toxicity relative to dose. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss. It is also potentially lethal when mixed with depressants like alcohol or benzodiazepines and generally has a wider range of substances

Dextropropoxyphene — SubstanceWiki

Dextropropoxyphene is an opioid analgesic patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive (cough suppressant) and local anesthetic effects. The drug has been taken off the market in Europe and the United States due to concerns of fatal overdoses and heart arrhythmias. It is still available in Australia, albeit with restrictions after an application by its manufacturer to review its proposed banning. Its onset of analgesia (pain relief) is said to be 20–30 minutes and peak effects are seen about 1.5–2.0 hours after oral administration.

Dextropropoxyphene is sometimes combined with paracetamol (acetaminophen). Trade names include Darvocet-N, Di-Gesic, and Darvon with APAP (for dextropropoxyphene and paracetamol). The British approved name (i.e. the generic name of the active ingredient) of the paracetamol/dextropropoxyphene preparation is co-proxamol (sold under a variety of brand names); however, it has been withdrawn since 2007, and is no longer available to new patients, with exceptions. The paracetamol combinations are known as Capadex or Di-Gesic in Australia, Lentogesic in South Africa, and Di-Antalvic in France (unlike co-proxamol, which is an approved name, these are all brand names).

Substance	Status	Note
3-Cl-PCP	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-HO-PCE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-HO-PCP	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-MeO-PCE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-MeO-PCMo	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
3-MeO-PCP	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
4-MeO-PCP	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Alcohol	Dangerous	—
Atropa belladonna	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Benzodiazepines	Dangerous	—
Cake	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Datura	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Deschloroetizolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Deschloroketamine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Desomorphine	Dangerous	Compounding respiratory depression and overdose risk
Diclazepam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Diphenhydramine	Dangerous	Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Diphenidine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Ephenidine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Eszopiclone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Etizolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Flubromazepam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Flubromazolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Flunitrazepam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Flunitrazolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Gaboxadol	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
GBL	Dangerous	—
GHB	Dangerous	—
Harmala alkaloid	Dangerous	Risk of serotonin syndrome and severe respiratory depression; potentially fatal
HXE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Inhalants	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Ketamine	Dangerous	—
Lorazepam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Memantine	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Mephenaqualone	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Metizolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Midazolam	Dangerous	Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
MXiPr	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Naloxone	Dangerous	Compounding respiratory depression and overdose risk
Nicotine	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Nifoxipam	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
O-PCE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
PCE	Dangerous	Both cause respiratory depression and unconsciousness; vomiting while dissociated risks aspiration
Peganum harmala	Dangerous	Risk of serotonin syndrome and severe respiratory depression; potentially fatal
Pentobarbital	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
Phenobarbital	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
SAMe	Dangerous	Severe respiratory depression risk; leading cause of polydrug overdose
3-FMA	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
4-MMC	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
8-Chlorotheophylline	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Adrafinil	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Benzydamine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Bromantane	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Dichloropane	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Ephedrine	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Hexedrone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Methcathinone	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Oxiracetam	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Phenylpiracetam	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Rhodiola Rosea	Caution	Stimulants mask opioid sedation, increasing overdose risk when the stimulant wears off
Nitrous	Uncertain	—
Psilocybin Mushrooms	Low Risk & No Synergy	No significant pharmacological interaction; opioids may slightly dull the psychedelic experience

Full	develops with prolonged and repeated use
Half	3 - 7 days
Zero	1 - 2 weeks

Dextropropoxyphene

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oral

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oral

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Physical(15)

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Cognitive(9)

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