2C-C

2C-C (2,5-dimethoxy-4-chlorophenethylamine) is a psychedelic phenethylamine of the 2C family, first synthesized and characterized by Alexander Shulgin and documented in PiHKAL (1991). It is distinguished within the 2C series by its reputation as the "gentle" member — producing milder, more manageable psychedelic effects at common doses (20–40 mg) with a comparatively relaxed character that community members frequently contrast with the more demanding intensity of 2C-E or the raw potency of 2C-P.

The 2C-C experience typically lasts 4–6 hours and is characterized by mild visual patterning, sensory enhancement, mood elevation, and a relaxed, occasionally sedated quality that sets it apart from the stimulant undercurrent present in many other 2C compounds. Users often describe an absence of the mental racing and analytical pressure that characterizes 2C-E, instead reporting a more contemplative, comfortable headspace. This profile has made 2C-C a popular choice for first-time 2C explorations and for those seeking a less demanding psychedelic experience.

The 4-chloro substituent — a halogen substitution at the 4-position of the phenyl ring — distinguishes 2C-C's pharmacology from its bromo and iodo siblings. The chloro group is the least lipophilic of the common 2C halogens, which appears to contribute to the compound's reduced potency and gentler character compared to 2C-B (4-bromo) or 2C-I (4-iodo). Like all 2C compounds, 2C-C is a Schedule I substance in the United States under the Federal Analogue Act framework, and explicitly scheduled in most other jurisdictions.