At a Glance
Dosage
oral
| Level | Ayahuasca | 4-AcO-DMT |
|---|---|---|
| Threshold | — | 5 mg |
| Light | — | 7.5–15 mg |
| Common | — | 15–25 mg |
| Strong | — | 25–45 mg |
| Heavy | — | 45 mg |
Only in 4-AcO-DMT
insufflated
| Level | Dose |
|---|---|
| Threshold | 5 mg |
| Light |
Duration
oral
Ayahuasca
oral
Total: 5 hrs – 10 hrsPeak
Offset
Afterglow
Onset20 min – 1 hrs
Peak1 hrs – 2 hrs
Offset1 hrs – 2 hrs
Afterglow1 hrs – 8 hrs
4-AcO-DMT
Effects
Safety
Interaction: Ayahuasca + 4-AcO-DMT
Low Risk & Synergy
Cross-tolerance exists; effects compound
Ayahuasca — Dangerous Interactions
No dangerous interactions recorded.
4-AcO-DMT — Dangerous Interactions
No dangerous interactions recorded.
Frequently Asked Questions
What is the difference between Ayahuasca and 4-AcO-DMT?
Ayahuasca is classified as a Psychedelic while 4-AcO-DMT is classified as a Psychedelic (Substituted tryptamines). They share 61 effects in common, with 15 effects unique to Ayahuasca and 43 unique to 4-AcO-DMT.
Is it safe to combine Ayahuasca and 4-AcO-DMT?
The interaction between Ayahuasca and 4-AcO-DMT is classified as "Low Risk & Synergy". Cross-tolerance exists; effects compound Always research interactions thoroughly before combining any substances.
Which is stronger, Ayahuasca or 4-AcO-DMT?
Both substances have different dose profiles and pharmacological mechanisms. Comparing "strength" directly is misleading — each has unique effects, durations, and safety considerations.