At a Glance
Dosage
oral
| Level | Methadone | Codeine |
|---|---|---|
| Threshold | 1 mg | 30 mg |
| Light | 3–5 mg | 50–100 mg |
| Common | 5–15 mg | 100–150 mg |
| Strong | 15–30 mg | 150–200 mg |
| Heavy | 30 mg | 200 mg |
Duration
oral
Methadone
oral
Total: 10 hrs – 19 hrsPeak
Offset
Afterglow
Onset20 min – 1.5 hrs
Come Up2 hrs – 4 hrs
Peak4 hrs – 6 hrs
Effects
Safety
Interaction: Methadone + Codeine
No direct interaction data available between these substances. This does not mean the combination is safe.
Methadone — Dangerous Interactions
Frequently Asked Questions
What is the difference between Methadone and Codeine?
Methadone is classified as a Opioids (Diphenylpropylamine) while Codeine is classified as a Opioids (Substituted morphinans). They share 30 effects in common, with 2 effects unique to Methadone and 2 unique to Codeine.
Is it safe to combine Methadone and Codeine?
There is no direct interaction data available for combining Methadone and Codeine. This does not mean the combination is safe. Always exercise caution and research thoroughly.
Which is stronger, Methadone or Codeine?
At common doses via oral, Methadone is typically dosed at 5–15 mg while Codeine is dosed at 100–150 mg. However, "stronger" depends on context — potency, subjective intensity, and duration all factor in. These substances have different pharmacological profiles and comparing raw potency is not straightforward.